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学科主题: 临床医学
题名:
Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies
作者: Li, XH; Chen, SU; Zhang, X; Tang, M; Kui, YR; Wu, XQ; Wang, S; Guo, YL
关键词: cortical granules ; cryopreservation ; gamete donation
刊名: HUMAN REPRODUCTION
发表日期: 2005-12-01
卷: 20, 期:12, 页:3390-3394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: INTRACYTOPLASMIC SPERM INJECTION ; IN-VITRO FERTILIZATION ; II HUMAN OOCYTES ; MEIOTIC SPINDLE ; MOUSE OOCYTES ; 1,2-PROPANEDIOL ; BIRTHS ; VITRIFICATION ; SURVIVAL ; BABIES
英文摘要:

BACKGROUND: Surplus oocytes in assisted reproduction treatment cycles could be saved and donated to other couples. ICSI is usually performed for oocytes that have been stored frozen, considering possible exocytosis of cortical granules (CG). The unavoidability of ICSI merits further study. METHODS: We used a slow method to freeze excess oocytes from infertile couples. After thawing, oocytes were fertilized by either IVF or ICSI according to semen parameters. Some oocytes were examined for CG. RESULTS: Twenty-eight infertile couples cryopreserved a proportion of their oocytes and 12 thawed their oocytes. Three couples used their own oocytes, whereas nine donated their oocytes to nine other couples for 12 cycles. The survival rate from thawing was 90% (73/81). The fertilization rate using IVF (83%) was similar to ICSI (82%). Seven pregnancies (47% per cycle) were achieved; one used her own oocytes and six received donated oocytes. Five women delivered six babies including one set of twins. Two pregnancies aborted. The frozen-thawed oocytes (15/15) revealed no exocytosis of CG. CONCLUSIONS: To freeze oocytes of infertile couples undergoing assisted reproduction treatment may help other couples. Our successful experience may facilitate oocyte banks to become a reality. Both IVF and ICSI are valuable for frozen oocytes.

语种: 英语
WOS记录号: WOS:000233668700019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64909
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Reprod & Genet Ctr, Beijing 100034, Peoples R China
2.Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan

Recommended Citation:
Li, XH,Chen, SU,Zhang, X,et al. Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies[J]. HUMAN REPRODUCTION,2005,20(12):3390-3394.
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