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学科主题临床医学
Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies
Li, XH; Chen, SU; Zhang, X; Tang, M; Kui, YR; Wu, XQ; Wang, S; Guo, YL
关键词cortical granules cryopreservation gamete donation
刊名HUMAN REPRODUCTION
2005-12-01
20期:12页:3390-3394
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]INTRACYTOPLASMIC SPERM INJECTION ; IN-VITRO FERTILIZATION ; II HUMAN OOCYTES ; MEIOTIC SPINDLE ; MOUSE OOCYTES ; 1,2-PROPANEDIOL ; BIRTHS ; VITRIFICATION ; SURVIVAL ; BABIES
英文摘要

BACKGROUND: Surplus oocytes in assisted reproduction treatment cycles could be saved and donated to other couples. ICSI is usually performed for oocytes that have been stored frozen, considering possible exocytosis of cortical granules (CG). The unavoidability of ICSI merits further study. METHODS: We used a slow method to freeze excess oocytes from infertile couples. After thawing, oocytes were fertilized by either IVF or ICSI according to semen parameters. Some oocytes were examined for CG. RESULTS: Twenty-eight infertile couples cryopreserved a proportion of their oocytes and 12 thawed their oocytes. Three couples used their own oocytes, whereas nine donated their oocytes to nine other couples for 12 cycles. The survival rate from thawing was 90% (73/81). The fertilization rate using IVF (83%) was similar to ICSI (82%). Seven pregnancies (47% per cycle) were achieved; one used her own oocytes and six received donated oocytes. Five women delivered six babies including one set of twins. Two pregnancies aborted. The frozen-thawed oocytes (15/15) revealed no exocytosis of CG. CONCLUSIONS: To freeze oocytes of infertile couples undergoing assisted reproduction treatment may help other couples. Our successful experience may facilitate oocyte banks to become a reality. Both IVF and ICSI are valuable for frozen oocytes.

语种英语
WOS记录号WOS:000233668700019
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64909
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Reprod & Genet Ctr, Beijing 100034, Peoples R China
2.Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
推荐引用方式
GB/T 7714
Li, XH,Chen, SU,Zhang, X,et al. Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies[J]. HUMAN REPRODUCTION,2005,20(12):3390-3394.
APA Li, XH.,Chen, SU.,Zhang, X.,Tang, M.,Kui, YR.,...&Guo, YL.(2005).Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies.HUMAN REPRODUCTION,20(12),3390-3394.
MLA Li, XH,et al."Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies".HUMAN REPRODUCTION 20.12(2005):3390-3394.
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