IR@PKUHSC  > 北京大学药学院
学科主题药学
3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells
Zhang, Shi-Ping1,2; Du, Xin-Gang3; Pu, Xiao-Ping1,2
关键词3-O-demethylswertipunicoside neuroprotection PC 12 cell 1-methyl-4-phenylpyridinium ion tyrosine hydroxylase DJ-1
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2010-09-01
33期:9页:1529-1533
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TYROSINE-HYDROXYLASE ; PARKINSONS-DISEASE ; 1-METHYL-4-PHENYLPYRIDINIUM ION ; DOPAMINERGIC-NEURONS ; PROTOCATECHUIC ACID ; HYDROGEN-PEROXIDE ; SUBSTANTIA-NIGRA ; SWERTIA-PUNICEA ; MPTP MODEL ; IN-VITRO
英文摘要

Xanthone compounds have been reported to inhibit cancer cell growth as well as possessing antioxidant properties. The xanthone compound 3-O-demethylswertipunicoside (3-ODS), extracted from Swertia punicea HEMSL, has not previously been demonstrated to have clear neuroprotective effects. In our study, the 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell death assay revealed that treatment of PC12 cells with 3-ODS ameliorated the decreased cell viability induced by exposure to 1-methyl-4-phenylpyridinium ion (M PP), rotenone or H2O2. The acridine orange/ethidium bromide (AO/EB) apoptosis assay demonstrated a significant suppression of cell death in PC12 cells. by 3-ODS treatment. 3-ODS increased the protein expression of both tyrosine hydroxylase (TH) and DJ-1 expression in PC12 cells. The current study demonstrates that 3-ODS has potential neuroprotective effects mediated via the elevation of TH and DJ-1 protein levels.

语种英语
所属项目编号30973889
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000281427600013
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64913
Collection北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nat Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Shi-Ping,Du, Xin-Gang,Pu, Xiao-Ping. 3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(9):1529-1533.
APA Zhang, Shi-Ping,Du, Xin-Gang,&Pu, Xiao-Ping.(2010).3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,33(9),1529-1533.
MLA Zhang, Shi-Ping,et al."3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 33.9(2010):1529-1533.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhang, Shi-Ping]'s Articles
[Du, Xin-Gang]'s Articles
[Pu, Xiao-Ping]'s Articles
百度学术
百度学术Similar articles in
[Zhang, Shi-Ping]'s Articles
[Du, Xin-Gang]'s Articles
[Pu, Xiao-Ping]'s Articles
必应学术
必应学术Similar articles in
[Zhang, Shi-Ping]'s Articles
[Du, Xin-Gang]'s Articles
[Pu, Xiao-Ping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.