北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells
作者: Zhang, Shi-Ping1,2; Du, Xin-Gang3; Pu, Xiao-Ping1,2
关键词: 3-O-demethylswertipunicoside ; neuroprotection ; PC 12 cell ; 1-methyl-4-phenylpyridinium ion ; tyrosine hydroxylase ; DJ-1
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2010-09-01
卷: 33, 期:9, 页:1529-1533
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TYROSINE-HYDROXYLASE ; PARKINSONS-DISEASE ; 1-METHYL-4-PHENYLPYRIDINIUM ION ; DOPAMINERGIC-NEURONS ; PROTOCATECHUIC ACID ; HYDROGEN-PEROXIDE ; SUBSTANTIA-NIGRA ; SWERTIA-PUNICEA ; MPTP MODEL ; IN-VITRO
英文摘要:

Xanthone compounds have been reported to inhibit cancer cell growth as well as possessing antioxidant properties. The xanthone compound 3-O-demethylswertipunicoside (3-ODS), extracted from Swertia punicea HEMSL, has not previously been demonstrated to have clear neuroprotective effects. In our study, the 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell death assay revealed that treatment of PC12 cells with 3-ODS ameliorated the decreased cell viability induced by exposure to 1-methyl-4-phenylpyridinium ion (M PP), rotenone or H2O2. The acridine orange/ethidium bromide (AO/EB) apoptosis assay demonstrated a significant suppression of cell death in PC12 cells. by 3-ODS treatment. 3-ODS increased the protein expression of both tyrosine hydroxylase (TH) and DJ-1 expression in PC12 cells. The current study demonstrates that 3-ODS has potential neuroprotective effects mediated via the elevation of TH and DJ-1 protein levels.

语种: 英语
所属项目编号: 30973889
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000281427600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64913
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nat Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Shi-Ping,Du, Xin-Gang,Pu, Xiao-Ping. 3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(9):1529-1533.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Shi-Ping]'s Articles
[Du, Xin-Gang]'s Articles
[Pu, Xiao-Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Shi-Ping]‘s Articles
[Du, Xin-Gang]‘s Articles
[Pu, Xiao-Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace