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学科主题: 药学
题名:
3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells
作者: Zhang, Shi-Ping1,2; Du, Xin-Gang3; Pu, Xiao-Ping1,2
关键词: 3-O-demethylswertipunicoside ; neuroprotection ; PC 12 cell ; 1-methyl-4-phenylpyridinium ion ; tyrosine hydroxylase ; DJ-1
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2010-09-01
卷: 33, 期:9, 页:1529-1533
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TYROSINE-HYDROXYLASE ; PARKINSONS-DISEASE ; 1-METHYL-4-PHENYLPYRIDINIUM ION ; DOPAMINERGIC-NEURONS ; PROTOCATECHUIC ACID ; HYDROGEN-PEROXIDE ; SUBSTANTIA-NIGRA ; SWERTIA-PUNICEA ; MPTP MODEL ; IN-VITRO
英文摘要:

Xanthone compounds have been reported to inhibit cancer cell growth as well as possessing antioxidant properties. The xanthone compound 3-O-demethylswertipunicoside (3-ODS), extracted from Swertia punicea HEMSL, has not previously been demonstrated to have clear neuroprotective effects. In our study, the 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell death assay revealed that treatment of PC12 cells with 3-ODS ameliorated the decreased cell viability induced by exposure to 1-methyl-4-phenylpyridinium ion (M PP), rotenone or H2O2. The acridine orange/ethidium bromide (AO/EB) apoptosis assay demonstrated a significant suppression of cell death in PC12 cells. by 3-ODS treatment. 3-ODS increased the protein expression of both tyrosine hydroxylase (TH) and DJ-1 expression in PC12 cells. The current study demonstrates that 3-ODS has potential neuroprotective effects mediated via the elevation of TH and DJ-1 protein levels.

语种: 英语
所属项目编号: 30973889
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000281427600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64913
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nat Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Shi-Ping,Du, Xin-Gang,Pu, Xiao-Ping. 3-O-Demethylswertipunicoside Protects against Oxidative Toxicity in PC12 Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(9):1529-1533.
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