IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate
Liu, Yanxing1; Zhang, Hailin1; Li, Xuepei2; Wang, Yongli1; Lu, Hong3; Qi, Xiang4; Ma, Changsheng1; Liu, Junxiu2
关键词salicylate voltage-gated sodium channel current delayed rectifier potassium channel current L-type voltage-gated calcium channel current auditory cortex
刊名NEUROPHARMACOLOGY
2007-12-01
DOI10.1016/j.neuropharm.2007.08.015
53期:7页:870-880
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]INFERIOR COLLICULUS NEURONS ; HIPPOCAMPAL-NEURONS ; CALCIUM-CHANNELS ; ANIMAL-MODEL ; C-FOS ; TINNITUS ; SODIUM ; ACTIVATION ; OUTWARD
英文摘要

Salicylate is a medicine for anti -inflammation with a side effect of tinnitus. To understand the mechanisms of tinnitus induced by salicylate, we studied the effects of salicylate on voltage-gated ion channels and action potential firing rates in freshly dissociated rat pyramidal neurons in auditory cortex (AC) using the whole-cell patch technique. We found that salicylate reduced the voltage-gated sodium Current (I-Na), the delayed rectifier potassium current (I-K(DR)) and the L-type voltage-gated calcium current (I-CA,I-I.) in concentration-dependent manner. An amount of 1 mM salicylate shifted the steady-state inactivation curve Of INa negatively by about 5 mV, shifted the steady-state activation and inactivation curve of I-K(DR) negatively by approximately 14 mV and 17 mV, respectively, and shifted the steady-state activation curve of I-CA,I-I. negatively by about 10 mV. 1 mM salicylate significantly increased the action potential firing rates, ultimately, From the results, we speculated that through affecting the voltage-gated ion channels in AC, an important position in auditory system. salicylate increased the firing rate of neurons and enhanced neuronal excitability on the one hand, increased the excitatory transmitters release and reduced the inhibitory transmitter release on the other hand, thus finally induced tinnitus. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000251536100009
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64919
Collection北京大学第三临床医学院_耳鼻喉科
作者单位1.Hebei Med Univ, Dept Pharmacol & Neurobiol, Shijiazhuang 050017, Hubei, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
3.Hebei Med Univ Second Hosp, Dept Otorhinolaryngol, Shijiazhuang 050000, Hebei, Peoples R China
4.Hebei Med Univ Second Hosp, Dept Anesthesiol, Shijiazhuang 050000, Hebei, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanxing,Zhang, Hailin,Li, Xuepei,et al. Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate[J]. NEUROPHARMACOLOGY,2007,53(7):870-880.
APA Liu, Yanxing.,Zhang, Hailin.,Li, Xuepei.,Wang, Yongli.,Lu, Hong.,...&Liu, Junxiu.(2007).Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate.NEUROPHARMACOLOGY,53(7),870-880.
MLA Liu, Yanxing,et al."Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate".NEUROPHARMACOLOGY 53.7(2007):870-880.
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