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IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科  > 期刊论文
学科主题: 临床医学
题名:
Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate
作者: Liu, Yanxing1; Zhang, Hailin1; Li, Xuepei2; Wang, Yongli1; Lu, Hong3; Qi, Xiang4; Ma, Changsheng1; Liu, Junxiu2
关键词: salicylate ; voltage-gated sodium channel current ; delayed rectifier potassium channel current ; L-type voltage-gated calcium channel current ; auditory cortex
刊名: NEUROPHARMACOLOGY
发表日期: 2007-12-01
DOI: 10.1016/j.neuropharm.2007.08.015
卷: 53, 期:7, 页:870-880
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: INFERIOR COLLICULUS NEURONS ; HIPPOCAMPAL-NEURONS ; CALCIUM-CHANNELS ; ANIMAL-MODEL ; C-FOS ; TINNITUS ; SODIUM ; ACTIVATION ; OUTWARD
英文摘要:

Salicylate is a medicine for anti -inflammation with a side effect of tinnitus. To understand the mechanisms of tinnitus induced by salicylate, we studied the effects of salicylate on voltage-gated ion channels and action potential firing rates in freshly dissociated rat pyramidal neurons in auditory cortex (AC) using the whole-cell patch technique. We found that salicylate reduced the voltage-gated sodium Current (I-Na), the delayed rectifier potassium current (I-K(DR)) and the L-type voltage-gated calcium current (I-CA,I-I.) in concentration-dependent manner. An amount of 1 mM salicylate shifted the steady-state inactivation curve Of INa negatively by about 5 mV, shifted the steady-state activation and inactivation curve of I-K(DR) negatively by approximately 14 mV and 17 mV, respectively, and shifted the steady-state activation curve of I-CA,I-I. negatively by about 10 mV. 1 mM salicylate significantly increased the action potential firing rates, ultimately, From the results, we speculated that through affecting the voltage-gated ion channels in AC, an important position in auditory system. salicylate increased the firing rate of neurons and enhanced neuronal excitability on the one hand, increased the excitatory transmitters release and reduced the inhibitory transmitter release on the other hand, thus finally induced tinnitus. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000251536100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64919
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Hebei Med Univ, Dept Pharmacol & Neurobiol, Shijiazhuang 050017, Hubei, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
3.Hebei Med Univ Second Hosp, Dept Otorhinolaryngol, Shijiazhuang 050000, Hebei, Peoples R China
4.Hebei Med Univ Second Hosp, Dept Anesthesiol, Shijiazhuang 050000, Hebei, Peoples R China

Recommended Citation:
Liu, Yanxing,Zhang, Hailin,Li, Xuepei,et al. Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate[J]. NEUROPHARMACOLOGY,2007,53(7):870-880.
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