IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科
学科主题临床医学
Identification of a human subcortical maternal complex
Zhu, Kai1,2; Yan, Liying3,4; Zhang, Xiaoxin1; Lu, Xukun1,2; Wang, Tianren3,4; Yan, Jie3,4; Liu, Xinqi5; Qiao, Jie3,4; Li, Lei1
关键词development maternal factor genes SCMC NLRP5 female infertility
刊名MOLECULAR HUMAN REPRODUCTION
2015-04-01
DOI10.1093/molehr/gau116
21期:4页:320-329
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]RECURRENT HYDATIDIFORM MOLE ; EARLY EMBRYONIC-DEVELOPMENT ; EFFECT GENE ; MIDBLASTULA TRANSITION ; REPRODUCTIVE WASTAGE ; MOUSE EMBRYOGENESIS ; OOCYTE GROWTH ; MUTATIONS ; EXPRESSION ; DROSOPHILA
英文摘要

Maternal effect genes play essential roles in early embryonic development. However, the mechanisms by which maternal effect genes regulate mammalian early embryonic development remain largely unknown. Recently, we identified a subcortical maternal complex (SCMC) that is composed of at least four proteins encoded by Mater, Floped, Tle6 and Filia and is critical for mouse preimplantation development. The present study demonstrates that human SCMC homologous genes (NLRP5, OOEP, TLE6 and KHDC3L) are specifically expressed in the oocytes of human fetal ovaries. The proteins of this complex co-localize in the subcortex of human oocytes and early embryos. Furthermore, the SCMC proteins physically interact with each other when they are co-expressed in cell lines. These results indicate that human NLRP5, OOEP, TLE6 and KHDC3L function as a complex in the oocytes and early embryos of Homo sapiens. Considering the important roles of the SCMC in mouse early embryogenesis, the characterization of the human SCMC will provide a basis for investigating human early embryonic development and will have clinical implications in human female infertility or recurrent spontaneous abortion.

语种英语
WOS记录号WOS:000353566500003
项目编号2011CB944501 ; 2012CB944401 ; 2012CB944404 ; 31171382 ; 30971655 ; 31230047 ; XDA01010103
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Hundred Talents Program of Chinese Academy of Sciences
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64920
专题北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
作者单位1.Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
5.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Kai,Yan, Liying,Zhang, Xiaoxin,et al. Identification of a human subcortical maternal complex[J]. MOLECULAR HUMAN REPRODUCTION,2015,21(4):320-329.
APA Zhu, Kai.,Yan, Liying.,Zhang, Xiaoxin.,Lu, Xukun.,Wang, Tianren.,...&Li, Lei.(2015).Identification of a human subcortical maternal complex.MOLECULAR HUMAN REPRODUCTION,21(4),320-329.
MLA Zhu, Kai,et al."Identification of a human subcortical maternal complex".MOLECULAR HUMAN REPRODUCTION 21.4(2015):320-329.
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