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学科主题: 临床医学
题名:
Identification of a human subcortical maternal complex
作者: Zhu, Kai1,2; Yan, Liying3,4; Zhang, Xiaoxin1; Lu, Xukun1,2; Wang, Tianren3,4; Yan, Jie3,4; Liu, Xinqi5; Qiao, Jie3,4; Li, Lei1
关键词: development ; maternal factor genes ; SCMC ; NLRP5 ; female infertility
刊名: MOLECULAR HUMAN REPRODUCTION
发表日期: 2015-04-01
DOI: 10.1093/molehr/gau116
卷: 21, 期:4, 页:320-329
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: RECURRENT HYDATIDIFORM MOLE ; EARLY EMBRYONIC-DEVELOPMENT ; EFFECT GENE ; MIDBLASTULA TRANSITION ; REPRODUCTIVE WASTAGE ; MOUSE EMBRYOGENESIS ; OOCYTE GROWTH ; MUTATIONS ; EXPRESSION ; DROSOPHILA
英文摘要:

Maternal effect genes play essential roles in early embryonic development. However, the mechanisms by which maternal effect genes regulate mammalian early embryonic development remain largely unknown. Recently, we identified a subcortical maternal complex (SCMC) that is composed of at least four proteins encoded by Mater, Floped, Tle6 and Filia and is critical for mouse preimplantation development. The present study demonstrates that human SCMC homologous genes (NLRP5, OOEP, TLE6 and KHDC3L) are specifically expressed in the oocytes of human fetal ovaries. The proteins of this complex co-localize in the subcortex of human oocytes and early embryos. Furthermore, the SCMC proteins physically interact with each other when they are co-expressed in cell lines. These results indicate that human NLRP5, OOEP, TLE6 and KHDC3L function as a complex in the oocytes and early embryos of Homo sapiens. Considering the important roles of the SCMC in mouse early embryogenesis, the characterization of the human SCMC will provide a basis for investigating human early embryonic development and will have clinical implications in human female infertility or recurrent spontaneous abortion.

语种: 英语
所属项目编号: 2011CB944501 ; 2012CB944401 ; 2012CB944404 ; 31171382 ; 30971655 ; 31230047 ; XDA01010103
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Hundred Talents Program of Chinese Academy of Sciences
WOS记录号: WOS:000353566500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64920
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
5.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

Recommended Citation:
Zhu, Kai,Yan, Liying,Zhang, Xiaoxin,et al. Identification of a human subcortical maternal complex[J]. MOLECULAR HUMAN REPRODUCTION,2015,21(4):320-329.
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