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学科主题: 药物依赖
题名:
Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats
作者: Ding, Zeng-Bo1; Wu, Ping1; Luo, Yi-Xiao1; Shi, Hai-Shui2; Shen, Hao-Wei1; Wang, Shen-Jun1; Lu, Lin1
关键词: Cocaine ; Consolidation ; Reconsolidation ; Nucleus accumbens ; Amygdala ; Conditioned place preference
刊名: PSYCHOPHARMACOLOGY
发表日期: 2013-08-01
DOI: 10.1007/s00213-013-3050-8
卷: 228, 期:3, 页:427-437
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; LONG-TERM POTENTIATION ; STIMULUS-REWARD MEMORY ; RHO-GTPASES ; SIGNALING PATHWAY ; VENTRAL STRIATUM ; INDUCED REINSTATEMENT ; PROTEIN-SYNTHESIS ; CONTEXTUAL FEAR ; DRUG-ADDICTION
英文摘要:

Drug reinforcement and the reinstatement of drug seeking are associated with the pathological processing of drug-associated cue memories that can be disrupted by manipulating memory consolidation and reconsolidation. Ras-related C3 botulinum toxin substrate (Rac) is involved in memory processing by regulating actin dynamics and neural structure plasticity. The nucleus accumbens (NAc) and amygdala have been implicated in the consolidation and reconsolidation of emotional memories. Therefore, we hypothesized that Rac in the NAc and amygdala plays a role in the consolidation and reconsolidation of cocaine-associated cue memory.

Conditioned place preference (CPP) and microinjection of Rac inhibitor NSC23766 were used to determine the role of Rac in the NAc and amygdala in the consolidation and reconsolidation of cocaine-associated cue memory in rats.

Microinjections of NSC23766 into the NAc core but not shell, basolateral (BLA), or central amygdala (CeA) after each cocaine-conditioning session inhibited the consolidation of cocaine-induced CPP. A microinjection of NSC23766 into the BLA but not CeA, NAc core, or NAc shell immediately after memory reactivation induced by exposure to a previously cocaine-paired context disrupted the reconsolidation of cocaine-induced CPP. The effect of memory disruption on cocaine reconsolidation was specific to reactivated memory, persisted at least 2 weeks, and was not reinstated by a cocaine-priming injection.

Our findings indicate that Rac in the NAc core and BLA are required for the consolidation and reconsolidation of cocaine-associated cue memory, respectively.

语种: 英语
所属项目编号: 2009CB522004 ; 81201032 ; 31230033 ; 31070958
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000321588300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64924
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang 050017, Peoples R China

Recommended Citation:
Ding, Zeng-Bo,Wu, Ping,Luo, Yi-Xiao,et al. Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats[J]. PSYCHOPHARMACOLOGY,2013,228(3):427-437.
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