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Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats
Ding, Zeng-Bo1; Wu, Ping1; Luo, Yi-Xiao1; Shi, Hai-Shui2; Shen, Hao-Wei1; Wang, Shen-Jun1; Lu, Lin1
关键词Cocaine Consolidation Reconsolidation Nucleus accumbens Amygdala Conditioned place preference
刊名PSYCHOPHARMACOLOGY
2013-08-01
DOI10.1007/s00213-013-3050-8
228期:3页:427-437
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CONDITIONED PLACE PREFERENCE ; LONG-TERM POTENTIATION ; STIMULUS-REWARD MEMORY ; RHO-GTPASES ; SIGNALING PATHWAY ; VENTRAL STRIATUM ; INDUCED REINSTATEMENT ; PROTEIN-SYNTHESIS ; CONTEXTUAL FEAR ; DRUG-ADDICTION
英文摘要

Drug reinforcement and the reinstatement of drug seeking are associated with the pathological processing of drug-associated cue memories that can be disrupted by manipulating memory consolidation and reconsolidation. Ras-related C3 botulinum toxin substrate (Rac) is involved in memory processing by regulating actin dynamics and neural structure plasticity. The nucleus accumbens (NAc) and amygdala have been implicated in the consolidation and reconsolidation of emotional memories. Therefore, we hypothesized that Rac in the NAc and amygdala plays a role in the consolidation and reconsolidation of cocaine-associated cue memory.

Conditioned place preference (CPP) and microinjection of Rac inhibitor NSC23766 were used to determine the role of Rac in the NAc and amygdala in the consolidation and reconsolidation of cocaine-associated cue memory in rats.

Microinjections of NSC23766 into the NAc core but not shell, basolateral (BLA), or central amygdala (CeA) after each cocaine-conditioning session inhibited the consolidation of cocaine-induced CPP. A microinjection of NSC23766 into the BLA but not CeA, NAc core, or NAc shell immediately after memory reactivation induced by exposure to a previously cocaine-paired context disrupted the reconsolidation of cocaine-induced CPP. The effect of memory disruption on cocaine reconsolidation was specific to reactivated memory, persisted at least 2 weeks, and was not reinstated by a cocaine-priming injection.

Our findings indicate that Rac in the NAc core and BLA are required for the consolidation and reconsolidation of cocaine-associated cue memory, respectively.

语种英语
WOS记录号WOS:000321588300009
项目编号2009CB522004 ; 81201032 ; 31230033 ; 31070958
资助机构National Basic Research Program of China ; Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64924
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang 050017, Peoples R China
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GB/T 7714
Ding, Zeng-Bo,Wu, Ping,Luo, Yi-Xiao,et al. Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats[J]. PSYCHOPHARMACOLOGY,2013,228(3):427-437.
APA Ding, Zeng-Bo.,Wu, Ping.,Luo, Yi-Xiao.,Shi, Hai-Shui.,Shen, Hao-Wei.,...&Lu, Lin.(2013).Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats.PSYCHOPHARMACOLOGY,228(3),427-437.
MLA Ding, Zeng-Bo,et al."Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats".PSYCHOPHARMACOLOGY 228.3(2013):427-437.
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