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学科主题临床医学
Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients
Xu, Rong1; Zhang, Lu-Xia1; Zhang, Pu-Hong2,3; Wang, Fang1; Zuo, Li1; Wang, Hai-Yan1
关键词chronic kidney disease glomerular filtration rate gender aging
刊名BMC NEPHROLOGY
2010-08-23
DOI10.1186/1471-2369-11-20
11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]RENAL HEMODYNAMIC-RESPONSE ; PROGRESSION ; PREVALENCE ; DONORS ; POPULATION ; MICROALBUMINURIA ; EXPRESSION ; EQUATION ; IMPACT ; ADULTS
英文摘要

Background: Since men with chronic kidney disease (CKD) progress faster than women, an accurate assessment of CKD progression rates should be based on gender differences in age-related decline of glomerular filtration rate (GFR) in healthy individuals.

Methods: A Chinese sample population from a stratified, multistage, and clustered CKD screening study was classified into healthy, at-risk, and CKD groups. The gender differences in estimated GFR (eGFR) and age-related eGFR decline were calculated for each group after controlling for blood pressure, fasting glucose levels, serum lipids levels, education level, and smoking status. After referencing to the healthy group, gender-specific multivariate-adjusted rates of decline in eGFR and differences in the rates of decline were calculated for both CKD and at-risk groups.

Results: The healthy, at-risk, and CKD groups consisted of 4569, 7434, and 1573 people, respectively. In all the 3 groups, the multivariate-adjusted eGFRs in men were lower than the corresponding eGFRs in women. In addition, in the healthy and at-risk groups, the rates of decline in eGFR in men were lower than the corresponding rates of decline in women (healthy group: 0.51 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.74 mL.min(-1).1.73 m(-2).yr(-1) and at-risk group: 0.60 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.73 mL.min(-1).1.73 m(-2).yr(-1)). However, in the CKD group, the rates of decline in eGFR in men were similar to those in women (0.96 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.91 mL.min(-1).1.73 m(-2).yr(-1)). However, after referencing to the healthy group, the rates of decline in eGFR in men in the at-risk and CKD groups were greater faster than the corresponding rates in women (at-risk group: 0.10 mL.min(-1).1.73 m(-2).yr(-1) vs. -0.03 mL.min(-1).1.73 m(-2).yr(-1) and CKD group: 0.44 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.15 mL.min(-1).1.73 m(-2).yr(-1)).

Conclusion: To accurately assess gender differences in CKD progression rates, gender differences in age-related decline in GFR should be considered.

语种英语
WOS记录号WOS:000283343100002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64927
专题北京大学第一临床医学院_肾脏内科
作者单位1.Ctr Prevent Med Res, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
3.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xu, Rong,Zhang, Lu-Xia,Zhang, Pu-Hong,et al. Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients[J]. BMC NEPHROLOGY,2010,11.
APA Xu, Rong,Zhang, Lu-Xia,Zhang, Pu-Hong,Wang, Fang,Zuo, Li,&Wang, Hai-Yan.(2010).Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients.BMC NEPHROLOGY,11.
MLA Xu, Rong,et al."Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients".BMC NEPHROLOGY 11(2010).
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