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学科主题: 临床医学
题名:
Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients
作者: Xu, Rong1; Zhang, Lu-Xia1; Zhang, Pu-Hong2,3; Wang, Fang1; Zuo, Li1; Wang, Hai-Yan1
关键词: chronic kidney disease ; glomerular filtration rate ; gender ; aging
刊名: BMC NEPHROLOGY
发表日期: 2010-08-23
DOI: 10.1186/1471-2369-11-20
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: RENAL HEMODYNAMIC-RESPONSE ; PROGRESSION ; PREVALENCE ; DONORS ; POPULATION ; MICROALBUMINURIA ; EXPRESSION ; EQUATION ; IMPACT ; ADULTS
英文摘要:

Background: Since men with chronic kidney disease (CKD) progress faster than women, an accurate assessment of CKD progression rates should be based on gender differences in age-related decline of glomerular filtration rate (GFR) in healthy individuals.

Methods: A Chinese sample population from a stratified, multistage, and clustered CKD screening study was classified into healthy, at-risk, and CKD groups. The gender differences in estimated GFR (eGFR) and age-related eGFR decline were calculated for each group after controlling for blood pressure, fasting glucose levels, serum lipids levels, education level, and smoking status. After referencing to the healthy group, gender-specific multivariate-adjusted rates of decline in eGFR and differences in the rates of decline were calculated for both CKD and at-risk groups.

Results: The healthy, at-risk, and CKD groups consisted of 4569, 7434, and 1573 people, respectively. In all the 3 groups, the multivariate-adjusted eGFRs in men were lower than the corresponding eGFRs in women. In addition, in the healthy and at-risk groups, the rates of decline in eGFR in men were lower than the corresponding rates of decline in women (healthy group: 0.51 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.74 mL.min(-1).1.73 m(-2).yr(-1) and at-risk group: 0.60 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.73 mL.min(-1).1.73 m(-2).yr(-1)). However, in the CKD group, the rates of decline in eGFR in men were similar to those in women (0.96 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.91 mL.min(-1).1.73 m(-2).yr(-1)). However, after referencing to the healthy group, the rates of decline in eGFR in men in the at-risk and CKD groups were greater faster than the corresponding rates in women (at-risk group: 0.10 mL.min(-1).1.73 m(-2).yr(-1) vs. -0.03 mL.min(-1).1.73 m(-2).yr(-1) and CKD group: 0.44 mL.min(-1).1.73 m(-2).yr(-1) vs. 0.15 mL.min(-1).1.73 m(-2).yr(-1)).

Conclusion: To accurately assess gender differences in CKD progression rates, gender differences in age-related decline in GFR should be considered.

语种: 英语
WOS记录号: WOS:000283343100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64927
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Ctr Prevent Med Res, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
3.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China

Recommended Citation:
Xu, Rong,Zhang, Lu-Xia,Zhang, Pu-Hong,et al. Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients[J]. BMC NEPHROLOGY,2010,11.
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