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学科主题临床医学
Adipocytokines: A bridge connecting obesity and insulin resistance
Zhuang, Xiao-Feng1; Zhao, Ming-Ming2; Weng, Cui-Lian1; Sun, Ning-Ling1
刊名MEDICAL HYPOTHESES
2009-12-01
DOI10.1016/j.mehy.2009.05.036
73期:6页:981-985
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]VISCERAL ADIPOSE-TISSUE ; MESSENGER-RNA EXPRESSION ; TNF-ALPHA ; SUBCUTANEOUS FAT ; 3T3-L1 ADIPOCYTES ; VASCULAR-DISEASE ; WEIGHT-LOSS ; PPAR-GAMMA ; ADIPONECTIN ; PROTEIN
英文摘要

Overweight or obesity has become a critical health problem in the world. The association of obesity with type 2 diabetes mellitus (T2D) has been recognized for decades, and the major basis for this link is the ability of obesity to engender insulin resistance (IR). Adipose tissue is not only an energy depot but also an active endocrine organ. Furthermore, fat distribution in the body is important for the progress of IR. Many studies show that visceral fat is more important in relation to IR than subcutaneous fat. Circulating free fatty acids (FFAs) derived from adipocytes are elevated in many IR states and have been suggested to be a main underlying mechanism of IR in obesity-associated T2D. However, compelling evidence demonstrates that adipocytokines including several adipocyte-derived cytokines or hormones are also involved in obesity-induced IR. Therefore, we hypothesise that adipocytokines may be a bridge connecting obesity and IR, and abnormal fat depot distribution or visceral fat/subcutaneous fat ratio (VIS ratio) in obesity also could be a primer for IR. When visceral fat accumulates and V/S ratio deteriorates, just like a primer,in visceral obesity it should begin to display unhealthy effect begin to take place in the body. In addition to it, as one of physiological regulation mechanisms of the body, most of the adipocytokines from the visceral fat reduce the visceral fat volume or normalize the V/S ratio. Actually, on the contrary, with serum a change in the serum adipocytokine level and an imbalance of them in the body for a long term, it will become a pathological condition and various kinds of effects may contribute to the development of IR. If confirmed, this hypothesis may lead to the formulation of new pathogenesis and new therapeutic approaches to IR. For example, an effective slimming pill will be assessed in future on the basis of the decrease of V/S and serum adipocytokines level rather than of body weight. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000272923000028
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64935
专题北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhuang, Xiao-Feng,Zhao, Ming-Ming,Weng, Cui-Lian,et al. Adipocytokines: A bridge connecting obesity and insulin resistance[J]. MEDICAL HYPOTHESES,2009,73(6):981-985.
APA Zhuang, Xiao-Feng,Zhao, Ming-Ming,Weng, Cui-Lian,&Sun, Ning-Ling.(2009).Adipocytokines: A bridge connecting obesity and insulin resistance.MEDICAL HYPOTHESES,73(6),981-985.
MLA Zhuang, Xiao-Feng,et al."Adipocytokines: A bridge connecting obesity and insulin resistance".MEDICAL HYPOTHESES 73.6(2009):981-985.
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