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学科主题: 临床医学
题名:
Adipocytokines: A bridge connecting obesity and insulin resistance
作者: Zhuang, Xiao-Feng1; Zhao, Ming-Ming2; Weng, Cui-Lian1; Sun, Ning-Ling1
刊名: MEDICAL HYPOTHESES
发表日期: 2009-12-01
DOI: 10.1016/j.mehy.2009.05.036
卷: 73, 期:6, 页:981-985
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: VISCERAL ADIPOSE-TISSUE ; MESSENGER-RNA EXPRESSION ; TNF-ALPHA ; SUBCUTANEOUS FAT ; 3T3-L1 ADIPOCYTES ; VASCULAR-DISEASE ; WEIGHT-LOSS ; PPAR-GAMMA ; ADIPONECTIN ; PROTEIN
英文摘要:

Overweight or obesity has become a critical health problem in the world. The association of obesity with type 2 diabetes mellitus (T2D) has been recognized for decades, and the major basis for this link is the ability of obesity to engender insulin resistance (IR). Adipose tissue is not only an energy depot but also an active endocrine organ. Furthermore, fat distribution in the body is important for the progress of IR. Many studies show that visceral fat is more important in relation to IR than subcutaneous fat. Circulating free fatty acids (FFAs) derived from adipocytes are elevated in many IR states and have been suggested to be a main underlying mechanism of IR in obesity-associated T2D. However, compelling evidence demonstrates that adipocytokines including several adipocyte-derived cytokines or hormones are also involved in obesity-induced IR. Therefore, we hypothesise that adipocytokines may be a bridge connecting obesity and IR, and abnormal fat depot distribution or visceral fat/subcutaneous fat ratio (VIS ratio) in obesity also could be a primer for IR. When visceral fat accumulates and V/S ratio deteriorates, just like a primer,in visceral obesity it should begin to display unhealthy effect begin to take place in the body. In addition to it, as one of physiological regulation mechanisms of the body, most of the adipocytokines from the visceral fat reduce the visceral fat volume or normalize the V/S ratio. Actually, on the contrary, with serum a change in the serum adipocytokine level and an imbalance of them in the body for a long term, it will become a pathological condition and various kinds of effects may contribute to the development of IR. If confirmed, this hypothesis may lead to the formulation of new pathogenesis and new therapeutic approaches to IR. For example, an effective slimming pill will be assessed in future on the basis of the decrease of V/S and serum adipocytokines level rather than of body weight. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000272923000028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64935
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100044, Peoples R China

Recommended Citation:
Zhuang, Xiao-Feng,Zhao, Ming-Ming,Weng, Cui-Lian,et al. Adipocytokines: A bridge connecting obesity and insulin resistance[J]. MEDICAL HYPOTHESES,2009,73(6):981-985.
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