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学科主题临床医学
Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population
Lu, Xiaolan1; Guo, Jianping1; Zhou, Xujie2,3; Li, Ru1; Liu, Xia4; Zhao, Yi5; Zhu, Baoli6; Liu, Xiangyuan7; Xu, Jianhua8; Zhu, Ping9; Wu, Xinyu1; He, Jing1; Liu, Xu1; Zhang, Hong2,3; Li, Zhanguo1
刊名ANNALS OF THE RHEUMATIC DISEASES
2011-09-01
DOI10.1136/ard.2010.148072
70期:9页:1648-1651
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]AUTOIMMUNE-DISEASES ; REVISED CRITERIA ; PSORIASIS ; SUSCEPTIBILITY ; CLASSIFICATION ; VARIANTS ; GENES ; LCE3C
英文摘要

Objectives The deletion of LCE3C_LCE3B confers susceptibility to psoriasis and rheumatoid arthritis (RA) in Caucasians. The aim of this study was to investigate the variant involvement in RA in the Chinese Han population and to further explore its potential role in the susceptibility to systemic lupus erythematosus (SLE).

Methods LCE3C_LCE3B-del was genotyped in 898 patients with RA and 681 healthy controls. Two single nucleotide polymorphisms (SNPs, rs4112788 and rs4085613) in strong linkage disequilibrium with LCE3C_LCE3B-del were then genotyped in patients with RA (n=1222), SLE (n=870) and healthy controls (n=1031).

Results The deletion of LCE3C_LCE3B and SNPs rs4112788 and rs4085613 showed an association with RA (allele analysis: p=7.72x10(-4), OR 1.28, 95% CI 1.11 to 1.47; p=6.39x10(-4), OR 1.23, 95% CI 1.09 to 1.38; and p=5.38x10(-4), OR 1.23, 95% CI 1.10 to 1.39, respectively). The two SNPs were also significantly associated with SLE (allele analysis: p=7.68x10(-3), OR 1.19, 95% CI 1.05 to 1.36 and p=5.30x10(-3), OR 1.20, 95% CI 1.06 to 1.37).

Conclusions This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE.

语种英语
WOS记录号WOS:000293275600022
项目编号2010CB529100 ; 30972710 ; 2007A011
资助机构Major State Basic Research Development Program of China (973 Program) ; National Natural Science Foundation of China ; Beijing Science and Technology Star Plans
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64937
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100044, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China
5.Xuanwu Hosp, Dept Rheumatol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China
7.Peking Univ, Hosp 3, Dept Rheumatol, Beijing 100044, Peoples R China
8.Anhui Med Univ, Hosp 1, Dept Rheumatol, Hefei, Peoples R China
9.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Immunol, Xian 710032, Peoples R China
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GB/T 7714
Lu, Xiaolan,Guo, Jianping,Zhou, Xujie,et al. Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population[J]. ANNALS OF THE RHEUMATIC DISEASES,2011,70(9):1648-1651.
APA Lu, Xiaolan.,Guo, Jianping.,Zhou, Xujie.,Li, Ru.,Liu, Xia.,...&Li, Zhanguo.(2011).Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population.ANNALS OF THE RHEUMATIC DISEASES,70(9),1648-1651.
MLA Lu, Xiaolan,et al."Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population".ANNALS OF THE RHEUMATIC DISEASES 70.9(2011):1648-1651.
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