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学科主题口腔医学
Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing
Xu, Fanxing1,2; Zhang, Chenying2,3; Graves, Dana T.2
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/754802
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]MESENCHYMAL STEM-CELLS ; NECROSIS-FACTOR-ALPHA ; GLYCATION END-PRODUCTS ; FOOT ULCERS ; GROWTH-FACTORS ; MACROPHAGE ACTIVATION ; INSULIN-RESISTANCE ; PROINFLAMMATORY CYTOKINES ; MATRIX-METALLOPROTEINASES ; VASCULAR COMPLICATIONS
英文摘要

Impaired diabetic wound healing constitutes a major health problem.. e impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-alpha also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-alpha.

语种英语
WOS记录号WOS:000314952500001
项目编号DE019108
资助机构NIDCR
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64948
专题北京大学口腔医学院_口腔预防保健科
作者单位1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China
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GB/T 7714
Xu, Fanxing,Zhang, Chenying,Graves, Dana T.. Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Xu, Fanxing,Zhang, Chenying,&Graves, Dana T..(2013).Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing.BIOMED RESEARCH INTERNATIONAL.
MLA Xu, Fanxing,et al."Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing".BIOMED RESEARCH INTERNATIONAL (2013).
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