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学科主题: 口腔医学
题名:
Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing
作者: Xu, Fanxing1,2; Zhang, Chenying2,3; Graves, Dana T.2
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/754802
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: MESENCHYMAL STEM-CELLS ; NECROSIS-FACTOR-ALPHA ; GLYCATION END-PRODUCTS ; FOOT ULCERS ; GROWTH-FACTORS ; MACROPHAGE ACTIVATION ; INSULIN-RESISTANCE ; PROINFLAMMATORY CYTOKINES ; MATRIX-METALLOPROTEINASES ; VASCULAR COMPLICATIONS
英文摘要:

Impaired diabetic wound healing constitutes a major health problem.. e impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-alpha also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-alpha.

语种: 英语
所属项目编号: DE019108
项目资助者: NIDCR
WOS记录号: WOS:000314952500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64948
Appears in Collections:北京大学口腔医学院_口腔预防保健科_期刊论文

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作者单位: 1.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China

Recommended Citation:
Xu, Fanxing,Zhang, Chenying,Graves, Dana T.. Abnormal Cell Responses and Role of TNF-alpha in Impaired Diabetic Wound Healing[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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