北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Inhibition of acrylamide toxicity in mice by three dietary constituents
作者: Xie, Qunying1; Liu, Ye1; Sun, Hongfang1; Liu, Yuanfang1; Ding, Xingfang2; Fu, Dongpo2; Liu, Kexin2; Du, Xianmei3; Jia, Guang3
关键词: acrylamide-biomacromolecule adducts ; tea polyphenol ; resveratrol ; diallyl trisulfide ; inhibition ; creatine kinase ; glutathione S-transferase ; accelerator mass spectrometry
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
发表日期: 2008-08-13
DOI: 10.1021/jf0730542
卷: 56, 期:15, 页:6054-6060
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: HEMOGLOBIN ADDUCTS ; N-ACETYLCYSTEINE ; CREATINE-KINASE ; RATS ; GLYCIDAMIDE ; DNA ; GENOTOXICITY ; METABOLISM ; NEUROPATHY ; BRAIN
英文摘要:

inhibitory effects of three dietary constituents, tea polyphenols, resveratrol, and diallyl trisulfide, on acrylamide-biomacromolecule (liver DNA, prolamine, and hemoglobin) adduct formation at human exposure level were studied by accelerator mass spectrometry. The results demonstrated that the three dietary constituents all significantly inhibited the formation of acrylamide adducts with liver DNA, whereas tea polyphenols and diallyl trisulfide reduced prolamine and hemoglobin adducts, respectively. Further biochemical studies showed that acrylamide could significantly inactivate creatine kinase and glutathione S-transferase and deplete glutathione. When the inhibitors were cotreated with acrylamide, all of them could effectively recover the activities of creatine kinase. In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably. On the basis of these results, mechanisms of the effects are discussed. This study might provide a beneficial guide to people′s diet for the purpose of reducing the harmful effect of acrylamide.

语种: 英语
WOS记录号: WOS:000258270300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64950
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nucl Phys & Technol, Coll Chem & Mol Engn, Dept Biol Chem,Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Xie, Qunying,Liu, Ye,Sun, Hongfang,et al. Inhibition of acrylamide toxicity in mice by three dietary constituents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(15):6054-6060.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xie, Qunying]'s Articles
[Liu, Ye]'s Articles
[Sun, Hongfang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xie, Qunying]‘s Articles
[Liu, Ye]‘s Articles
[Sun, Hongfang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace