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Inhibition of acrylamide toxicity in mice by three dietary constituents
Xie, Qunying1; Liu, Ye1; Sun, Hongfang1; Liu, Yuanfang1; Ding, Xingfang2; Fu, Dongpo2; Liu, Kexin2; Du, Xianmei3; Jia, Guang3
关键词acrylamide-biomacromolecule adducts tea polyphenol resveratrol diallyl trisulfide inhibition creatine kinase glutathione S-transferase accelerator mass spectrometry
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2008-08-13
DOI10.1021/jf0730542
56期:15页:6054-6060
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]HEMOGLOBIN ADDUCTS ; N-ACETYLCYSTEINE ; CREATINE-KINASE ; RATS ; GLYCIDAMIDE ; DNA ; GENOTOXICITY ; METABOLISM ; NEUROPATHY ; BRAIN
英文摘要

inhibitory effects of three dietary constituents, tea polyphenols, resveratrol, and diallyl trisulfide, on acrylamide-biomacromolecule (liver DNA, prolamine, and hemoglobin) adduct formation at human exposure level were studied by accelerator mass spectrometry. The results demonstrated that the three dietary constituents all significantly inhibited the formation of acrylamide adducts with liver DNA, whereas tea polyphenols and diallyl trisulfide reduced prolamine and hemoglobin adducts, respectively. Further biochemical studies showed that acrylamide could significantly inactivate creatine kinase and glutathione S-transferase and deplete glutathione. When the inhibitors were cotreated with acrylamide, all of them could effectively recover the activities of creatine kinase. In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably. On the basis of these results, mechanisms of the effects are discussed. This study might provide a beneficial guide to people′s diet for the purpose of reducing the harmful effect of acrylamide.

语种英语
WOS记录号WOS:000258270300012
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64950
专题北京大学公共卫生学院
作者单位1.Peking Univ, State Key Lab Nucl Phys & Technol, Coll Chem & Mol Engn, Dept Biol Chem,Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Xie, Qunying,Liu, Ye,Sun, Hongfang,et al. Inhibition of acrylamide toxicity in mice by three dietary constituents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(15):6054-6060.
APA Xie, Qunying.,Liu, Ye.,Sun, Hongfang.,Liu, Yuanfang.,Ding, Xingfang.,...&Jia, Guang.(2008).Inhibition of acrylamide toxicity in mice by three dietary constituents.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(15),6054-6060.
MLA Xie, Qunying,et al."Inhibition of acrylamide toxicity in mice by three dietary constituents".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.15(2008):6054-6060.
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