IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling
Jiang, Wen G.1,2; Ye, Lin1,2; Ji, Ke1,2; Ruge, Fiona1,2; Wu, Yiling3; Gao, Yong3; Ji, Jiafu1,4; Mason, Malcolm D.1,2
关键词osteosarcoma in vivo model Yangzheng Xiaoji cell adhesion focal adhesion kinase electric cell-substrate impedance sensing paxillin integrin
刊名ONCOLOGY REPORTS
2013-09-01
DOI10.3892/or.2013.2586
30期:3页:1405-1413
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER-CELLS ; IN-VITRO ; GROWTH ; ANGIOGENESIS ; INHIBITION ; IMPACT ; METASTASIS ; EXPRESSION ; MIGRATION ; ADJUVANT
英文摘要

The present study examined, in vitro and in vivo, the potential antitumour effects of Yangzheng Xiaoji (YZXJ), a traditional Chinese medical formula used in cancer treatment, on osteosarcoma, a tumour type recently found to be sensitive to YZXJ. The human osteosarcoma cell line MG63 was used in cell-matrix adhesion and cell growth assays. The same cell line was used in an in vivo tumour model by establishing subcutaneous osteosarcoma xenografts. Oral and intraperitoneal routes were used to deliver the YZXJ extract. The effect of YZXJ on the activation of focal adhesion kinase (FAK) and paxillin was evaluated by immunofluorescence methods. It was found that YZXJ exhibited a significant inhibitory effect on cell-matrix adhesion as demonstrated by a cell-based assay and electric cell-substrate impedance sensing (ECIS) analysis. The effect was observed together with a reduction in phospho-FAK and phospho-paxillin in the cells when treated with YZXJ. In the in vivo tumour model, YZXJ was found to significantly inhibit the growth of osteosarcoma with a sustained effect observed when YZXJ was delivered intraperitoneally. YZXJ sensitized cells to the effect of FAK inhibitor in vitro and in vivo. It is concluded that Yangzheng Xiaoji plays a significant role in cell-matrix adhesion and tumour growth, likely by inhibiting the activation of the FAK pathway. The therapeutic role of Yangzheng Xiaoji in osteosarcoma warrants further investigation.

语种英语
WOS记录号WOS:000322384700050
资助机构Cancer Research Wales ; Albert Hung Foundation
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64952
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Cardiff Univ Peking Univ Sch Oncol Joint Inst, Beijing, Peoples R China
2.Cardiff Univ, Sch Med, Inst Canc & Genet, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
3.Yiling Med Res Inst Tianshan Dajie, Shijiazhuang, Hebei, Peoples R China
4.Peking Univ, Canc Hosp, Dept Gastroenterol Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Wen G.,Ye, Lin,Ji, Ke,et al. Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling[J]. ONCOLOGY REPORTS,2013,30(3):1405-1413.
APA Jiang, Wen G..,Ye, Lin.,Ji, Ke.,Ruge, Fiona.,Wu, Yiling.,...&Mason, Malcolm D..(2013).Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling.ONCOLOGY REPORTS,30(3),1405-1413.
MLA Jiang, Wen G.,et al."Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling".ONCOLOGY REPORTS 30.3(2013):1405-1413.
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