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Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice
Jin, Shasha; Chang, Cuiqing; Zhang, Lantao; Liu, Yang; Huang, Xianren; Chen, Zhimin
刊名PLOS ONE
2015-04-07
DOI10.1371/journal.pone.0120842
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACTIVATED PROTEIN-KINASE ; GROWTH-FACTOR-BETA ; COFFEE CONSUMPTION ; GLUCOSE-TOLERANCE ; DECAFFEINATED COFFEE ; GLUT4 TRANSLOCATION ; SKELETAL-MUSCLE ; ADIPOSE-TISSUE ; LONG-TERM ; METABOLISM
英文摘要

The aim of this study was to examine the effects of chlorogenic acid (CGA) on glucose and lipid metabolism in late diabetic db/db mice, as well as on adiponectin receptors and their signaling molecules, to provide evidence for CGA in the prevention of type 2 diabetes. We randomly divided 16 female db/db mice into db/db-CGA and db/db-control (CON) groups equally; db/m mice were used as control mice. The mice in both the db/db-CGA and db/m-CGA groups were administered 80 mg/kg/d CGA by lavage for 12 weeks, whereas the mice in both CON groups were given equal volumes of phosphate-buffered saline (PBS) by lavage. At the end of the intervention, we assessed body fat and the parameters of glucose and lipid metabolism in the plasma, liver and skeletal muscle tissues as well as the levels of aldose reductase (AR) and transforming growth factor-beta 1 (TGF-beta 1) in the kidneys and measured adiponectin receptors and the protein expression of their signaling molecules in liver and muscle tissues. After 12 weeks of intervention, compared with the db/db-CON group, the percentage of body fat, fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) in the db/db-CGA group were all significantly decreased; TGF-beta 1 protein expression and AR activity in the kidney were both decreased; and the adiponectin level in visceral adipose was increased. The protein expression of adiponectin receptors (ADPNRs), the phosphorylation of AMP-activated protein kinase (AMPK) in the liver and muscle, and the mRNA and protein levels of peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the liver were all significantly greater. CGA could lower the levels of fasting plasma glucose and HbA1c during late diabetes and improve kidney fibrosis to some extent through the modulation of adiponectin receptor signaling pathways in db/db mice.

语种英语
所属项目编号30872112
资助者National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China
WOS记录号WOS:000352477800035
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64955
专题北京大学第三临床医学院_运动医学研究所
作者单位Peking Univ, Hosp 3, Inst Sports Med, Beijing 100871, Peoples R China
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GB/T 7714
Jin, Shasha,Chang, Cuiqing,Zhang, Lantao,et al. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice[J]. PLOS ONE,2015,10(4).
APA Jin, Shasha,Chang, Cuiqing,Zhang, Lantao,Liu, Yang,Huang, Xianren,&Chen, Zhimin.(2015).Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice.PLOS ONE,10(4).
MLA Jin, Shasha,et al."Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice".PLOS ONE 10.4(2015).
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