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Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population
Jin, Lei1,2; Zhang, Le1,2; Li, Zhiwen1,2; Liu, Jian-meng1,2; Ye, Rrongwei1,2; Ren, Aiguo1,2
关键词Neural tube defects Anencephaly Spina bifida Birth defects Placenta Heavy metals Mercury Lead Cadmium Arsenic
刊名REPRODUCTIVE TOXICOLOGY
2013
DOI10.1016/j.reprotox.2012.10.015
35页:25-31
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Reproductive Biology ; Toxicology
研究领域[WOS]Reproductive Biology ; Toxicology
关键词[WOS]TOXIC TRACE-ELEMENTS ; MATERNAL ENVIRONMENT ; MONITORING FETAL ; DUAL BIOMARKER ; SHANXI PROVINCE ; METHYL MERCURY ; SWEDISH WOMEN ; CHICK-EMBRYOS ; PREGNANCY ; EXPOSURE
英文摘要

To examine whether in utero exposure to mercury (Hg), cadmium (Cd), lead (Pb) and arsenic (As) is associated with an elevated neural tube defects (NTDs) risk, placental concentrations of total Hg, Cd, Pb and As were measured with an inductively coupled plasma mass spectrometer (ICP-MS) in 36 anencephaly and 44 spina bifida cases as well as in 50 healthy controls. The median Hg concentration in the NTD cases (2.25 ng/g) was higher than that of the controls (1.16 ng/g). The odds ratio (OR) for an Hg concentration above the median was 8.80(95% CI 3.80-20.36) for the NTD cases. NTD risks increased for the second and third high levels of the concentrations, with ORs of 2.70 (95% CI 1.13-6.43) and 18.20(95% CI 5.45-60.73), respectively. Therefore, higher placental levels of Hg are associated with an elevated risk of NTDs. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000314003900004
项目编号31071315 ; 2010ZX01042-002-001-05
资助机构National Natural Science Foundation of China ; national major program on "Advanced Unstructured Data Repository, AUDR"
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64957
专题北京大学公共卫生学院_北京大学生育健康研究所
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jin, Lei,Zhang, Le,Li, Zhiwen,et al. Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population[J]. REPRODUCTIVE TOXICOLOGY,2013,35:25-31.
APA Jin, Lei,Zhang, Le,Li, Zhiwen,Liu, Jian-meng,Ye, Rrongwei,&Ren, Aiguo.(2013).Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population.REPRODUCTIVE TOXICOLOGY,35,25-31.
MLA Jin, Lei,et al."Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population".REPRODUCTIVE TOXICOLOGY 35(2013):25-31.
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