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学科主题: 公共卫生
题名:
Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population
作者: Jin, Lei1,2; Zhang, Le1,2; Li, Zhiwen1,2; Liu, Jian-meng1,2; Ye, Rrongwei1,2; Ren, Aiguo1,2
关键词: Neural tube defects ; Anencephaly ; Spina bifida ; Birth defects ; Placenta ; Heavy metals ; Mercury ; Lead ; Cadmium ; Arsenic
刊名: REPRODUCTIVE TOXICOLOGY
发表日期: 2013
DOI: 10.1016/j.reprotox.2012.10.015
卷: 35, 页:25-31
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology ; Toxicology
研究领域[WOS]: Reproductive Biology ; Toxicology
关键词[WOS]: TOXIC TRACE-ELEMENTS ; MATERNAL ENVIRONMENT ; MONITORING FETAL ; DUAL BIOMARKER ; SHANXI PROVINCE ; METHYL MERCURY ; SWEDISH WOMEN ; CHICK-EMBRYOS ; PREGNANCY ; EXPOSURE
英文摘要:

To examine whether in utero exposure to mercury (Hg), cadmium (Cd), lead (Pb) and arsenic (As) is associated with an elevated neural tube defects (NTDs) risk, placental concentrations of total Hg, Cd, Pb and As were measured with an inductively coupled plasma mass spectrometer (ICP-MS) in 36 anencephaly and 44 spina bifida cases as well as in 50 healthy controls. The median Hg concentration in the NTD cases (2.25 ng/g) was higher than that of the controls (1.16 ng/g). The odds ratio (OR) for an Hg concentration above the median was 8.80(95% CI 3.80-20.36) for the NTD cases. NTD risks increased for the second and third high levels of the concentrations, with ORs of 2.70 (95% CI 1.13-6.43) and 18.20(95% CI 5.45-60.73), respectively. Therefore, higher placental levels of Hg are associated with an elevated risk of NTDs. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 31071315 ; 2010ZX01042-002-001-05
项目资助者: National Natural Science Foundation of China ; national major program on "Advanced Unstructured Data Repository, AUDR"
WOS记录号: WOS:000314003900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64957
Appears in Collections:北京大学公共卫生学院_北京大学生育健康研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Reprod & Child Hlth, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Lei,Zhang, Le,Li, Zhiwen,et al. Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population[J]. REPRODUCTIVE TOXICOLOGY,2013,35:25-31.
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