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学科主题: 临床医学
题名:
Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males
作者: Dong, Qing1; Tang, Genfu2; He, Mingli3; Cai, Yunqing1; Cai, Yefeng4; Xing, Houxun5; Sun, Liming6; Li, Jianping7; Zhang, Yan7; Fan, Fangfang7; Wang, Binyan8; Sun, Ningling9; Liu, Lisheng10; Xu, Xiping11,12; Hou, Fanfan12; Shen, Hongbing1; Xu, Xin12; Huo, Yong7
关键词: MTHFR C677T polymorphism ; eGFR ; CKD
刊名: BMC MEDICAL GENETICS
发表日期: 2012-08-16
DOI: 10.1186/1471-2350-13-74
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: HYPERHOMOCYSTEINEMIC RATS ; RISK-FACTOR ; HOMOCYSTEINE ; METAANALYSIS ; INJURY ; ACTIVATION ; DISEASE ; KIDNEY ; STROKE ; MTHFR
英文摘要:

Background: Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.

Methods: A total of 18 814 hypertensive patients (6 914 males, 11 900 females) were included in the study.

Results: Association between the eGFR and MTHFR C677T genotype was examined by sex-specific regression analyses. In males, TT genotype was associated with 1.37 ml/min/1.73 m(2) decrease in eGFR (p = 0.004) and with an increased risk (OR = 1.32, p = 0.008) for the lowest quintile of eGFR after adjusting for age, BMI, and blood pressures. However, such association was not observed in females (p > 0.05). This association suggests MTHFR C677T polymorphism may play a role in the regulation of eGFR in males.

Conclusions: MTHFR 677 T is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease (CKD).

语种: 英语
所属项目编号: 2012CB517703
项目资助者: Major State Basic Research Development Program of China (973 program)
WOS记录号: WOS:000309424100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64960
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
2.First Peoples Hosp, Dept Neurol, Lianyungang, Peoples R China
3.Lianyungang Ctr Adv Res Cardiovasc Dis, Lianyungang, Peoples R China
4.Second Peoples Hosp, Dept Cardiol, Lianyungang, Peoples R China
5.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
6.Guangdong Tradit Chinese Med Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China
7.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
8.Shenzhen Univ, Inst Biomed, Guangzhou, Guangdong, Peoples R China
9.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
10.Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China
11.Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL 60642 USA
12.So Med Univ, Inst Nephrol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Dong, Qing,Tang, Genfu,He, Mingli,et al. Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males[J]. BMC MEDICAL GENETICS,2012,13.
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