IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males
Dong, Qing1; Tang, Genfu2; He, Mingli3; Cai, Yunqing1; Cai, Yefeng4; Xing, Houxun5; Sun, Liming6; Li, Jianping7; Zhang, Yan7; Fan, Fangfang7; Wang, Binyan8; Sun, Ningling9; Liu, Lisheng10; Xu, Xiping11,12; Hou, Fanfan12; Shen, Hongbing1; Xu, Xin12; Huo, Yong7
关键词MTHFR C677T polymorphism eGFR CKD
刊名BMC MEDICAL GENETICS
2012-08-16
DOI10.1186/1471-2350-13-74
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]HYPERHOMOCYSTEINEMIC RATS ; RISK-FACTOR ; HOMOCYSTEINE ; METAANALYSIS ; INJURY ; ACTIVATION ; DISEASE ; KIDNEY ; STROKE ; MTHFR
英文摘要

Background: Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.

Methods: A total of 18 814 hypertensive patients (6 914 males, 11 900 females) were included in the study.

Results: Association between the eGFR and MTHFR C677T genotype was examined by sex-specific regression analyses. In males, TT genotype was associated with 1.37 ml/min/1.73 m(2) decrease in eGFR (p = 0.004) and with an increased risk (OR = 1.32, p = 0.008) for the lowest quintile of eGFR after adjusting for age, BMI, and blood pressures. However, such association was not observed in females (p > 0.05). This association suggests MTHFR C677T polymorphism may play a role in the regulation of eGFR in males.

Conclusions: MTHFR 677 T is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease (CKD).

语种英语
WOS记录号WOS:000309424100002
项目编号2012CB517703
资助机构Major State Basic Research Development Program of China (973 program)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64960
专题北京大学第一临床医学院_心血管内科
作者单位1.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
2.First Peoples Hosp, Dept Neurol, Lianyungang, Peoples R China
3.Lianyungang Ctr Adv Res Cardiovasc Dis, Lianyungang, Peoples R China
4.Second Peoples Hosp, Dept Cardiol, Lianyungang, Peoples R China
5.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
6.Guangdong Tradit Chinese Med Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China
7.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
8.Shenzhen Univ, Inst Biomed, Guangzhou, Guangdong, Peoples R China
9.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
10.Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China
11.Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL 60642 USA
12.So Med Univ, Inst Nephrol, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Dong, Qing,Tang, Genfu,He, Mingli,et al. Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males[J]. BMC MEDICAL GENETICS,2012,13.
APA Dong, Qing.,Tang, Genfu.,He, Mingli.,Cai, Yunqing.,Cai, Yefeng.,...&Huo, Yong.(2012).Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males.BMC MEDICAL GENETICS,13.
MLA Dong, Qing,et al."Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males".BMC MEDICAL GENETICS 13(2012).
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