|Prognostic analysis of orthostatic intolerance using survival model in children|
|Li Yawen1; Li Hongxia2; Li Xueying1; Li Xiaoming3; Jin Hongfang2|
|关键词||survival analysis orthostatic intolerance children prognosis|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||POSTURAL TACHYCARDIA SYNDROME ; MIDODRINE HYDROCHLORIDE ; NEUROCARDIOGENIC SYNCOPE ; THERAPEUTIC EFFECTIVENESS ; UNEXPLAINED SYNCOPE ; PLASMA COPEPTIN ; ADOLESCENTS ; METOPROLOL ; MANAGEMENT ; EFFICACY|
Background Orthostatic intolerance (01) is a common disease at pediatric period which has a serious impact on physical and mental health of children. The purpose of this study was to investigate the effect of related factors on the prognosis of children with OI.
Methods The subjects were 170 children with 01, including 71 males (41.8%) and 99 females (58.2%) with age from 6 to 17 (12.0 +/- 2.6) years. The effect of related factors on the prognosis of children was studied by using univariate analysis. Then, the impact of children′s age, symptom score, duration, disease subtype, and treatment on patient′s prognosis was studied via analysis of COX proportional conversion model.
Results Among 170 cases, 48 were diagnosed with vasovagal syncope, including 28 cases of vasoinhibitory type, 16 cases of mixed type, and 4 cases of cardioinhibitory type; 115 cases were diagnosed with postural tachycardia syndrome and 7 cases with orthostatic hypotension. By using univariate analysis of Cox regression, the results showed that symptom score had a marked impact on the time of symptoms improvement of children after taking medication (P <0.05), while other univariates had no impact (P >0.05). Multivariate analysis using Cox proportional hazards regression model showed that the symptom score at diagnosis had a significant effect on holding time of symptoms improvement of children after taking medication (P <0.05). Kaplan-Meier curve showed that symptom-free survival was higher in children with symptom score equal to 1 than children with symptom score equal to or greater than 2 during follow-up (P <0.05).
Conclusion Symptom score is an important factor affecting the time of symptom improvement after treatment for children with OI.
|作者单位||1.Tsinghua Univ, Sch Econ & Management, Beijing 100084, Peoples R China|
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.South China Agr Univ, Guangzhou 510642, Guangdong, Peoples R China
|Li Yawen,Li Hongxia,Li Xueying,et al. Prognostic analysis of orthostatic intolerance using survival model in children[J]. CHINESE MEDICAL JOURNAL,2014,127(21):3690-3694.|
|APA||Li Yawen,Li Hongxia,Li Xueying,Li Xiaoming,&Jin Hongfang.(2014).Prognostic analysis of orthostatic intolerance using survival model in children.CHINESE MEDICAL JOURNAL,127(21),3690-3694.|
|MLA||Li Yawen,et al."Prognostic analysis of orthostatic intolerance using survival model in children".CHINESE MEDICAL JOURNAL 127.21(2014):3690-3694.|