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学科主题: 临床医学
题名:
Prognostic analysis of orthostatic intolerance using survival model in children
作者: Li Yawen1; Li Hongxia2; Li Xueying1; Li Xiaoming3; Jin Hongfang2
关键词: survival analysis ; orthostatic intolerance ; children ; prognosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-11-05
DOI: 10.3760/cma.j.issn.0366-6999.20140927
卷: 127, 期:21, 页:3690-3694
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: POSTURAL TACHYCARDIA SYNDROME ; MIDODRINE HYDROCHLORIDE ; NEUROCARDIOGENIC SYNCOPE ; THERAPEUTIC EFFECTIVENESS ; UNEXPLAINED SYNCOPE ; PLASMA COPEPTIN ; ADOLESCENTS ; METOPROLOL ; MANAGEMENT ; EFFICACY
英文摘要:

Background Orthostatic intolerance (01) is a common disease at pediatric period which has a serious impact on physical and mental health of children. The purpose of this study was to investigate the effect of related factors on the prognosis of children with OI.

Methods The subjects were 170 children with 01, including 71 males (41.8%) and 99 females (58.2%) with age from 6 to 17 (12.0 +/- 2.6) years. The effect of related factors on the prognosis of children was studied by using univariate analysis. Then, the impact of children′s age, symptom score, duration, disease subtype, and treatment on patient′s prognosis was studied via analysis of COX proportional conversion model.

Results Among 170 cases, 48 were diagnosed with vasovagal syncope, including 28 cases of vasoinhibitory type, 16 cases of mixed type, and 4 cases of cardioinhibitory type; 115 cases were diagnosed with postural tachycardia syndrome and 7 cases with orthostatic hypotension. By using univariate analysis of Cox regression, the results showed that symptom score had a marked impact on the time of symptoms improvement of children after taking medication (P <0.05), while other univariates had no impact (P >0.05). Multivariate analysis using Cox proportional hazards regression model showed that the symptom score at diagnosis had a significant effect on holding time of symptoms improvement of children after taking medication (P <0.05). Kaplan-Meier curve showed that symptom-free survival was higher in children with symptom score equal to 1 than children with symptom score equal to or greater than 2 during follow-up (P <0.05).

Conclusion Symptom score is an important factor affecting the time of symptom improvement after treatment for children with OI.

语种: 英语
WOS记录号: WOS:000346329300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64963
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Tsinghua Univ, Sch Econ & Management, Beijing 100084, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.South China Agr Univ, Guangzhou 510642, Guangdong, Peoples R China

Recommended Citation:
Li Yawen,Li Hongxia,Li Xueying,et al. Prognostic analysis of orthostatic intolerance using survival model in children[J]. CHINESE MEDICAL JOURNAL,2014,127(21):3690-3694.
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