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学科主题: 临床医学
题名:
The Role of Apelin in the Retina of Diabetic Rats
作者: Lu, Qiang1,2; Feng, Jing1,2; Jiang, Yan-rong1,2
刊名: PLOS ONE
发表日期: 2013-07-16
DOI: 10.1371/journal.pone.0069703
卷: 8, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; APJ RECEPTOR ; CELL-PROLIFERATION ; ENDOGENOUS LIGAND ; ANGIOGENIC FACTOR ; EXPRESSION ; RETINOPATHY ; PEPTIDE ; MICE ; VITREORETINOPATHY
英文摘要:

Purpose: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory effects.

Principal Findings: Strong staining of apelin, co-localized with glial fibrillary acidic protein (GFAP) and vascular endothelial growth factor (VEGF) was observed in the retina of diabetic rats. Apelin, GFAP, and VEGF mRNA and protein levels were significantly increased in the sample′s retinas. Moreover, exogenous apelin promoted retinal Muller cell proliferation in vivo. Simultaneously, apelin induced GFAP and VEGF expression. F13A markedly reduced retinal gliosis caused by diabetes. Furthermore, F13A suppressed both GFAP and VEGF expression in vivo.

Significance: Our results strongly suggest that apelin is associated with the development of DR and contributes to changes in the retinas of diabetic rats. Apelin induced promotion of cell proliferation lends support to the possibility that apelin may play a role in the progression of DR to a proliferative phase. This possible role deserves further investigation, which may offer new perspectives in the early prevention and treatment of DR.

语种: 英语
所属项目编号: 20100001110073 ; 20110001110042 ; 81271027
项目资助者: Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; EFSD/CDS/Lilly grant
WOS记录号: WOS:000322064300111
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64968
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Lu, Qiang,Feng, Jing,Jiang, Yan-rong. The Role of Apelin in the Retina of Diabetic Rats[J]. PLOS ONE,2013,8(7).
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