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The Role of Apelin in the Retina of Diabetic Rats
Lu, Qiang1,2; Feng, Jing1,2; Jiang, Yan-rong1,2
刊名PLOS ONE
2013-07-16
DOI10.1371/journal.pone.0069703
8期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; APJ RECEPTOR ; CELL-PROLIFERATION ; ENDOGENOUS LIGAND ; ANGIOGENIC FACTOR ; EXPRESSION ; RETINOPATHY ; PEPTIDE ; MICE ; VITREORETINOPATHY
英文摘要

Purpose: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory effects.

Principal Findings: Strong staining of apelin, co-localized with glial fibrillary acidic protein (GFAP) and vascular endothelial growth factor (VEGF) was observed in the retina of diabetic rats. Apelin, GFAP, and VEGF mRNA and protein levels were significantly increased in the sample′s retinas. Moreover, exogenous apelin promoted retinal Muller cell proliferation in vivo. Simultaneously, apelin induced GFAP and VEGF expression. F13A markedly reduced retinal gliosis caused by diabetes. Furthermore, F13A suppressed both GFAP and VEGF expression in vivo.

Significance: Our results strongly suggest that apelin is associated with the development of DR and contributes to changes in the retinas of diabetic rats. Apelin induced promotion of cell proliferation lends support to the possibility that apelin may play a role in the progression of DR to a proliferative phase. This possible role deserves further investigation, which may offer new perspectives in the early prevention and treatment of DR.

语种英语
WOS记录号WOS:000322064300111
项目编号20100001110073 ; 20110001110042 ; 81271027
资助机构Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; EFSD/CDS/Lilly grant
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64968
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
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GB/T 7714
Lu, Qiang,Feng, Jing,Jiang, Yan-rong. The Role of Apelin in the Retina of Diabetic Rats[J]. PLOS ONE,2013,8(7).
APA Lu, Qiang,Feng, Jing,&Jiang, Yan-rong.(2013).The Role of Apelin in the Retina of Diabetic Rats.PLOS ONE,8(7).
MLA Lu, Qiang,et al."The Role of Apelin in the Retina of Diabetic Rats".PLOS ONE 8.7(2013).
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