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学科主题: 临床医学
题名:
Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice
作者: Mori, T; Yamasaki, S; Masui, F; Matsuda, M; Sasabe, H; Zhou, YF
关键词: MMP inhibitor ; extracellular matrix ; adenomyosis ; mice
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2001-05-01
卷: 226, 期:5, 页:429-433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CELLS ; PROLACTIN
英文摘要:

The inhibitory effects of a novel, orally active matrix metalloproteinase (MMP) inhibitor, ONO-4817, on the development of uterine adenomyosis induced experimentally by pituitary grafting were examined in mice. Mice were given transplants of isologous anterior pituitary glands (PGs) into the right uterine lumen at 7 weeks of age and were fed chow containing 0.1% to 1.0% ONO-4817 from 8 to 14 weeks of age. Mice treated with 0.3% or 1.0% ONO-4817 showed a significantly lower incidence of the development of adenomyosis than vehicle-treated mice. To evaluate the inhibitory effects of ONO-4817 on the progression of the invasion of the adenomyotic tissues, mice receiving PG grafts at 7 weeks of age were treated with 1.0% ONO-4817 from 13 to 17 weeks of age. The degree of pathological progression of adenomyosis was graded from 1 to 5 in increments of 1. The degree of the progression of the lesion was less in the uteri exposed to ONO-4817(2.71 +/- 0.93) than in the uteri not exposed to the inhibitor (4.33 +/- 0.75), Finally, the invasiveness of endometrial stromal cells obtained from adenomyotic uteri into Matrigel consisting mainly of type IV collagen and laminin was examined using an invasion assay. The assay showed that the treatment with ONO-4817 markedly suppressed the invasion of the stromal cells of the adenomyotic uteri into the gel. These results indicate that ONO-4817 may be an effective inhibitor of the development of adenomyosis.

语种: 英语
WOS记录号: WOS:000168542500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64972
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan
2.Ono Pharmaceut Co, Minase Res Inst, Dept Res & Management, Osaka 6188585, Japan
3.Beijing Univ, Teaching Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China

Recommended Citation:
Mori, T,Yamasaki, S,Masui, F,et al. Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2001,226(5):429-433.
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