学科主题基础医学
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway
Yu, Chuanfei1,2; Han, Wenling1,2; Shi, Taiping1,2,3; Lv, Bingfeng1,2; He, Qihua4; Zhang, Yanfei1,2; Li, Ting1,2; Zhang, Yingmei1,2; Song, Quansheng1,2; Wang, Lu1,2; Ma, Dalong1,2,3
关键词14-3-3 Raf-1 ERK Migration
刊名CELLULAR SIGNALLING
2008-12-01
DOI10.1016/j.cellsig.2008.07.020
20期:12页:2208-2220
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]TYROSINE-PHOSPHATASE 1B ; EPIDERMAL-GROWTH-FACTOR ; NEGATIVE REGULATION ; IN-VIVO ; PHOSPHORYLATION SITES ; BREAST-CANCER ; PC12 CELLS ; KINASE-C ; ACTIVATION ; MIGRATION
英文摘要

Cell migration plays a critical role during the development of most organisms and the process of malignant tumor metastasis. In the present study, we investigated the role of PTPIP51 (protein tyrosine phosphatase interacting protein 51) in cell motility. Overexpression of PTPIP51 induced cell elongation, increased cell migration, adhesion, and spreading, while downregulation of PTPIP51 had the opposite effects. We demonstrated here, that PTPIP51 could regulate ERK activity on Raf level, since MEK inhibitor and dominant-negative Raf-1 but not Ras could inhibit the ERK activation induced by PTPIP51. Further studies proved that PTPIP51 could interact with Raf-1 through 14-3-3, suggesting that PTPIP51 is a regulator of the Raf-MEK-ERK cascade through modulation of Raf-1 by 14-3-3. In addition, two redundant 14-3-3 binding domains in the PTPIP51 protein have been identified by deletion/mutation studies. We conclude that PTPIP51 regulates cell morphology and cell motility via interaction with Raf-1 through 14-3-3, and that PTPIP51 binds to 14-3-3 through two redundant binding domains. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000261560800005
项目编号2006AA02A305
资助机构National High Technology Research and Development Program of China (863 Program)
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64974
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
3.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Hlth & Med Anal Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Yu, Chuanfei,Han, Wenling,Shi, Taiping,et al. PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway[J]. CELLULAR SIGNALLING,2008,20(12):2208-2220.
APA Yu, Chuanfei.,Han, Wenling.,Shi, Taiping.,Lv, Bingfeng.,He, Qihua.,...&Ma, Dalong.(2008).PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway.CELLULAR SIGNALLING,20(12),2208-2220.
MLA Yu, Chuanfei,et al."PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway".CELLULAR SIGNALLING 20.12(2008):2208-2220.
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