IR@PKUHSC  > 北京大学第一临床医学院  > 老年病内科
学科主题临床医学
Xuezhikang, Extract of Red Yeast Rice, Inhibited Tissue Factor and Hypercoagulable State Through Suppressing Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Extracellular Signal-regulated Kinase Activation
Li, Pei; Yang, YaBing; Liu, MeiLin
关键词atherosclerosis xuezhikang red yeast rice tissue factor NADPH oxidase
刊名JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
2011-09-01
DOI10.1097/FJC.0b013e3182244a2d
58期:3页:307-318
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]MYOCARDIAL-INFARCTION ; DISEASE ; ATHEROSCLEROSIS ; MECHANISMS ; CHOLESTIN ; PROTEIN ; EVENTS
英文摘要

Xuezhikang, extract of red yeast rice, is a traditional Chinese medicine with multiple cardioprotective effect. It contains a family of naturally occurring statins, such as lovastatin. Tissue factor (TF) is over-expressed in macrophages of lipid core plaques, which display high procoagulant activity and seem to be a potentially target for anti-atherothrombosis. Therefore, the purpose of this study was to explore the effect and possible molecular mechanisms of xuezhikang on inhibiting TF expression and hypercoagulable state and the differences compared with lovastatin. Our results showed that xuezhikang significantly suppressed oxidized low-density lipoprotein-induced TF expression in macrophages in a concentration-dependent manner. Xuezhikang reduced nicotinamide adenine dinucleotide phosphate oxidase activity by decreasing membrane translocation of p47(phox) through inhibition of extracellular signal-regulated kinase 1/2 activation. Nicotinamide adenine dinucleotide phosphate inhibitor (diphenyleneiodonium) also inhibited the oxidized low-density lipoprotein-induced TF expression, similar to the effects of xuezhikang. Furthermore, consistent with the severity of aortic atherosclerosis, xuezhikang (300 mg.kg(-1.)d(-1)) significantly reduced blood coagulation activation and TF expression in high-cholesterol diet-induced atherosclerotic rats. In addition, xuezhikang was more potent than lovastatin on inhibiting the expression of TF and nicotinamide adenine dinucleotide phosphate oxidase activation. These observations provide evidences that inhibition of xuezhikang on hypercoagulation and TF expression may partly account for its cardioprotective benefits.

语种英语
WOS记录号WOS:000294599400010
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64978
专题北京大学第一临床医学院_老年病内科
作者单位Peking Univ, Dept Geriatr, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, Pei,Yang, YaBing,Liu, MeiLin. Xuezhikang, Extract of Red Yeast Rice, Inhibited Tissue Factor and Hypercoagulable State Through Suppressing Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Extracellular Signal-regulated Kinase Activation[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2011,58(3):307-318.
APA Li, Pei,Yang, YaBing,&Liu, MeiLin.(2011).Xuezhikang, Extract of Red Yeast Rice, Inhibited Tissue Factor and Hypercoagulable State Through Suppressing Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Extracellular Signal-regulated Kinase Activation.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,58(3),307-318.
MLA Li, Pei,et al."Xuezhikang, Extract of Red Yeast Rice, Inhibited Tissue Factor and Hypercoagulable State Through Suppressing Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Extracellular Signal-regulated Kinase Activation".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 58.3(2011):307-318.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Pei]的文章
[Yang, YaBing]的文章
[Liu, MeiLin]的文章
百度学术
百度学术中相似的文章
[Li, Pei]的文章
[Yang, YaBing]的文章
[Liu, MeiLin]的文章
必应学术
必应学术中相似的文章
[Li, Pei]的文章
[Yang, YaBing]的文章
[Liu, MeiLin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。