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学科主题: 临床医学
题名:
Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis
作者: Tang, Haikuo1; Wu, Zhiyuan2; Zhang, Jianping3; Su, Bing4,5,6
关键词: oral squamous cell carcinoma ; long non-coding RNAs ; salivary
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2013-03-01
DOI: 10.3892/mmr.2012.1254
卷: 7, 期:3, 页:761-766
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: LONG NONCODING RNA ; PROSTATE-CANCER ; CLINICAL UTILITY ; LUNG-CANCER ; MICRORNA ; METASTASIS ; IDENTIFICATION ; PROGNOSIS ; BIOLOGY
英文摘要:

Oral squamous cell carcinoma (OSCC) is a common and lethal malignancy. Thus, improvement in current knowledge of molecular changes associated with OSCC is urgently needed to explore novel avenues of diagnostics and treatment of this disease. While aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with certain types of cancer, including lung, breast and prostate carcinomas, their expression pattern and biological relevance in OSCC is currently unknown. In the present study, the relative abundance of a collection of lncRNAs in tissue or saliva samples from OSCC patients was investigated. It was shown that subsets of lncRNAs are expressed across non-tumor, tumor and metastatic tissue samples. Some detected lncRNAs were shown to be aberrantly expressed in cases of oral cancer and metastasis. Moreover, whole saliva contained a detectable amount of some lncRNAs, which appeared to be potential markers for OSCC. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.

语种: 英语
所属项目编号: ZYA201106080030A ; 21610404 ; 50624023 ; 81102510
项目资助者: Research Grants of Shenzhen Science and Technology Project ; Fundamental Research Funds for the Central Universities of China ; Scientific Research Foundation of Jinan University ; Medical Science and Technology Foundation of Guangdong ; National Natural Science Foundation of China ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS记录号: WOS:000315423600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64980
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Affiliated Stomatol Hosp, Dept Oral & Maxicallifacial Surg, Guangzhou 510055, Guangdong, Peoples R China
2.Fudan Univ, Shanghai Med Sch, Huashan Hosp, Dept Lab Med, Shanghai 200040, Peoples R China
3.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
5.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China

Recommended Citation:
Tang, Haikuo,Wu, Zhiyuan,Zhang, Jianping,et al. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. MOLECULAR MEDICINE REPORTS,2013,7(3):761-766.
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