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学科主题: 基础医学
题名:
Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts
作者: Fang, Riguo1,2; Liu, Kang1,2; Zhao, Yang1,2; Li, Haibo2; Zhu, Dicong2,3; Du, Yuanyuan1,2; Xiang, Chengang1,2; Li, Xiang1,2; Liu, Haisong2,3; Miao, Zhenchuan4; Zhang, Xing1,2; Shi, Yan1,3; Yang, Weifeng4; Xu, Jun1,2; Deng, Hongkui1,2,3
刊名: CELL STEM CELL
发表日期: 2014-10-02
DOI: 10.1016/j.stem.2014.09.004
卷: 15, 期:4, 页:488-496
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: GROUND-STATE ; MAINTAINS PLURIPOTENCY ; TRANSCRIPTION FACTOR ; SMALL MOLECULES ; SOMATIC-CELLS ; SELF-RENEWAL ; MOUSE ; EPIBLAST ; LINES ; DERIVATION
英文摘要:

Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from primates resemble mouse epiblast stem cells, raising an intriguing question regarding whether the naive pluripotent state resembling mouse embryonic stem cells (mESCs) exists in primates and how to capture it in vitro. Here we identified several specific signaling modulators that are sufficient to generate rhesus monkey fibroblast-derived iPSCs with the features of naive pluripotency in terms of growth properties, gene expression profiles, self-renewal signaling, X-reactivation, and the potential to generate cross-species chimeric embryos. Interestingly, together with recent reports of naive human pluripotent stem cells, our findings suggest several conserved signaling pathways shared with rodents and specific to primates, providing significant in-sights for acquiring naive pluripotency from other species. In addition, the derivation of rhesus monkey naive iPSCs also provides a valuable cell source for use in preclinical research and disease modeling.

语种: 英语
所属项目编号: 2012CB966401 ; 91310305 ; 2013ZX10001003 ; 2013DFG30680
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Science and Technology Major Project ; Ministry of Science and Technology ; Ministry of Education of China (111 Project)
WOS记录号: WOS:000343235800014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64986
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: 1.Peking Univ, Peking Tsinghua Ctr Life Sci, Coll Life Sci, MOE Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Dept Cell Biol,Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen Stem Cell Engn Lab, Shenzhen 518055, Peoples R China
4.Beijing Vitalstar Biotechnol, Beijing 100012, Peoples R China

Recommended Citation:
Fang, Riguo,Liu, Kang,Zhao, Yang,et al. Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts[J]. CELL STEM CELL,2014,15(4):488-496.
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