北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Changes of ATP and ADP in cultured astrocytes under and after in vitro ischemia
作者: Yu, ACH; Lau, AMF; Fu, AWY; Lau, LT; Lam, PY; Chen, XQ; Xu, ZY
关键词: astrocytes ; culture ; in vitro ischemia ; energy metabolism ; ATP
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2002-12-01
卷: 27, 期:12, 页:1663-1668
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; CELL-CULTURES ; INJURY ; NEURONS ; INTERLEUKIN-6 ; GLUTAMATE ; IMMATURE ; HYPOXIA
英文摘要:

A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ischemia could induce apoptosis in astrocytes. In this study, we utilized the same in vitro model to investigate changes in ATP and ADP levels in cultured astrocytes and attempted to demonstrate an energy-cell death linkage. Astrocytes remained unaltered after 2 hr of ischemia but were moderately or severely damaged after 4 or 6-8 hr, respectively. The astrocytes that survived various lengths of in vitro ischemic incubation retained their ability to produce ATP after ischemia. Both ATP and ADP levels were increased in astrocytes that remained alive under in vitro ischemia for over 6 hr. The largest decline in the percent of viable astrocytes during ischemia corresponded well to the reduction in ATP and ADP levels in these cultures.

语种: 英语
WOS记录号: WOS:000179862800015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64992
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Changes of ATP and ADP in cultured astrocytes under and after in vitro ischemia.pdf(674KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100083, Peoples R China
3.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Yu, ACH,Lau, AMF,Fu, AWY,et al. Changes of ATP and ADP in cultured astrocytes under and after in vitro ischemia[J]. NEUROCHEMICAL RESEARCH,2002,27(12):1663-1668.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, ACH]'s Articles
[Lau, AMF]'s Articles
[Fu, AWY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, ACH]‘s Articles
[Lau, AMF]‘s Articles
[Fu, AWY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace