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学科主题口腔医学
FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis
Xiao, Wenmei1,2; Dong, Guangyu2; Pacios, Sandra2; Alnammary, Maher2; Barger, Laura A.2; Wang, Yu2,3; Wu, Yingying2; Graves, Dana T.2
刊名AMERICAN JOURNAL OF PATHOLOGY
2015-04-01
DOI10.1016/j.ajpath.2014.12.006
185期:4页:1085-1093
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]INDUCED BONE LOSS ; OSTEOPROTEGERIN LIGAND ; TISSUE DESTRUCTION ; LANGERHANS CELLS ; T-CELLS ; INFLAMMATION ; INFECTION ; DISEASE ; RESORPTION ; CYTOKINES
英文摘要

The host response plays both protective and destructive roles in periodontitis. FOX01 is a transcription factor that is activated in dendritic cells (DCs), but its function in vivo has not been examined. We investigated the rote of FOX01 in activating DCs in experimental (CD11c.Cre(+).FOX01(L/L)) compared with matched control mice (CD11c.Cre(-).FOX01(L/L)) in response to oral pathogens. Lineage-specific FOX01 deletion reduced the recruitment of DCs to oral mucosal epithelium by approximately 40%. FOX01 was needed for expression of genes that regulate migration, including integrins alpha nu and beta 3 and matrix metalloproteinase-2. Ablation of FOX01 in DCs significantly decreased IL-12 produced by DCs in mucosal surfaces. Moreover, FOX01 deletion reduced migration of DCs to lymph nodes, reduced capacity of DCs to induce formation of plasma cells, and reduced production of bacteria-specific antibody. The decrease in DC function in the experimental mice led to increased susceptibility to periodontitis through a mechanism that involved a compensatory increase in osteoclastogenic factors, IL-1 beta, IL-17, and RANKL. Thus, we reveal a critical role for FOX01 in DC recruitment to oral mucosal epithelium and activation of adaptive immunity induced by oral inoculation of bacteria.

语种英语
WOS记录号WOS:000351787600018
项目编号DE-017732 ; DE-021921 ; P30 AR050950
资助机构National Institute of Dental and Craniofacial Research ; Penn Center for Musculoskeletal Disorders, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64999
专题北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100871, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Jilin Univ, Sch Stomatol, Dept Implantol, Changchun 130023, Peoples R China
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GB/T 7714
Xiao, Wenmei,Dong, Guangyu,Pacios, Sandra,et al. FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis[J]. AMERICAN JOURNAL OF PATHOLOGY,2015,185(4):1085-1093.
APA Xiao, Wenmei.,Dong, Guangyu.,Pacios, Sandra.,Alnammary, Maher.,Barger, Laura A..,...&Graves, Dana T..(2015).FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis.AMERICAN JOURNAL OF PATHOLOGY,185(4),1085-1093.
MLA Xiao, Wenmei,et al."FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis".AMERICAN JOURNAL OF PATHOLOGY 185.4(2015):1085-1093.
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