北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis
作者: Xiao, Wenmei1,2; Dong, Guangyu2; Pacios, Sandra2; Alnammary, Maher2; Barger, Laura A.2; Wang, Yu2,3; Wu, Yingying2; Graves, Dana T.2
刊名: AMERICAN JOURNAL OF PATHOLOGY
发表日期: 2015-04-01
DOI: 10.1016/j.ajpath.2014.12.006
卷: 185, 期:4, 页:1085-1093
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: INDUCED BONE LOSS ; OSTEOPROTEGERIN LIGAND ; TISSUE DESTRUCTION ; LANGERHANS CELLS ; T-CELLS ; INFLAMMATION ; INFECTION ; DISEASE ; RESORPTION ; CYTOKINES
英文摘要:

The host response plays both protective and destructive roles in periodontitis. FOX01 is a transcription factor that is activated in dendritic cells (DCs), but its function in vivo has not been examined. We investigated the rote of FOX01 in activating DCs in experimental (CD11c.Cre(+).FOX01(L/L)) compared with matched control mice (CD11c.Cre(-).FOX01(L/L)) in response to oral pathogens. Lineage-specific FOX01 deletion reduced the recruitment of DCs to oral mucosal epithelium by approximately 40%. FOX01 was needed for expression of genes that regulate migration, including integrins alpha nu and beta 3 and matrix metalloproteinase-2. Ablation of FOX01 in DCs significantly decreased IL-12 produced by DCs in mucosal surfaces. Moreover, FOX01 deletion reduced migration of DCs to lymph nodes, reduced capacity of DCs to induce formation of plasma cells, and reduced production of bacteria-specific antibody. The decrease in DC function in the experimental mice led to increased susceptibility to periodontitis through a mechanism that involved a compensatory increase in osteoclastogenic factors, IL-1 beta, IL-17, and RANKL. Thus, we reveal a critical role for FOX01 in DC recruitment to oral mucosal epithelium and activation of adaptive immunity induced by oral inoculation of bacteria.

语种: 英语
所属项目编号: DE-017732 ; DE-021921 ; P30 AR050950
项目资助者: National Institute of Dental and Craniofacial Research ; Penn Center for Musculoskeletal Disorders, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
WOS记录号: WOS:000351787600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64999
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100871, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Jilin Univ, Sch Stomatol, Dept Implantol, Changchun 130023, Peoples R China

Recommended Citation:
Xiao, Wenmei,Dong, Guangyu,Pacios, Sandra,et al. FOX01 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis[J]. AMERICAN JOURNAL OF PATHOLOGY,2015,185(4):1085-1093.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiao, Wenmei]'s Articles
[Dong, Guangyu]'s Articles
[Pacios, Sandra]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiao, Wenmei]‘s Articles
[Dong, Guangyu]‘s Articles
[Pacios, Sandra]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace