|The clinical outcomes of day 3 4-cell embryos after extended in vitro culture|
|Zhao, Ping1,2,3; Li, Ming1,2,3; Lian, Ying1,2,3; Zheng, Xiaoying1,2,3; Liu, Ping1,2,3; Qiao, Jie1,2,3|
|关键词||Day 3 4-cell embryos Blastocyst Frozen embryo transfer Slowly cleavage embryo|
|刊名||JOURNAL OF ASSISTED REPRODUCTION AND GENETICS|
|WOS标题词||Science & Technology|
|类目[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||HUMAN PREIMPLANTATION EMBRYOS ; BLASTOCYST DEVELOPMENT ; IMPLANTATION RATES ; PREDICTIVE-VALUE ; MORPHOLOGY ; PREGNANCY ; FERTILIZATION ; CLEAVAGE ; QUALITY ; TRANSFERS|
To evaluate the development potential and clinical significance of day 3 4-cell embryos after extended in vitro culture.
This study was a retrospective cohort study for patients with infertility treatment between January 2011 and July 2013. Patients undergoing blastocyst culture in controlled ovarian hyperstimulation cycles using surplus embryos were analyzed in the study. A total of 764 women undergoing blastocyst culture with 1,522 surplus 4-cell embryos on day 3 were analyzed. An additional 2,391 patients with embryos undergoing blastocyst culture during the same period with embryos having more blastomeres were chosen as control.
After extended culture, 253 embryos from 183 cycles in the study group which developed to blastocysts were frozen, and 118 embryos were warmed in subsequent frozen embryo transfer cycles. Implantation rates, clinical pregnancy rates (PRs) and ongoing PRs were 33.3 %, 38.4 % and 31.4 %, respectively, which were similar to those of the control group. The singleton birth weights of newborns using these blastocysts showed no significant difference to that seen in the control group.
Surplus 4-cell embryos on day 3 displayed lower blastulation rates. However, once a blastocyst is obtained, it has equivalent clinical outcomes. Embryos that are developmentally lagging on day 3 can be observed in extended culture to increase the cumulative chances of a successful pregnancy.
|作者单位||1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China|
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100871, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
|Zhao, Ping,Li, Ming,Lian, Ying,et al. The clinical outcomes of day 3 4-cell embryos after extended in vitro culture[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2015,32(1):55-60.|
|APA||Zhao, Ping,Li, Ming,Lian, Ying,Zheng, Xiaoying,Liu, Ping,&Qiao, Jie.(2015).The clinical outcomes of day 3 4-cell embryos after extended in vitro culture.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,32(1),55-60.|
|MLA||Zhao, Ping,et al."The clinical outcomes of day 3 4-cell embryos after extended in vitro culture".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 32.1(2015):55-60.|