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学科主题: 临床医学
题名:
Detection of human cytomegalovirus (CMV) DNA in feces has limited value in predicting CMV enteritis in patients with intestinal graft-versus-host disease after allogeneic stem cell transplantation
作者: Sun, Y. -Q.1; Xu, L. -P.1; Han, T. -T.1; Zhang, X. -H.1; Wang, Y.1; Han, W.1; Wang, F. -R.1; Wang, J. -Z.1; Chen, H.1; Chen, Y. -H.1; Yan, C. -H.1; Chen, Y.1; Liu, K. -Y.1; Huang, X. -J.1,2
关键词: stem cell transplantation ; diarrhea ; cytomegalovirus ; graft-versus-host disease ; feces
刊名: TRANSPLANT INFECTIOUS DISEASE
发表日期: 2015-10-01
DOI: 10.1111/tid.12420
卷: 17, 期:5, 页:655-661
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Transplantation
研究领域[WOS]: Immunology ; Infectious Diseases ; Transplantation
关键词[WOS]: DIAGNOSIS ; RECIPIENTS ; GASTROENTERITIS ; EXPERIENCE ; VIRUSES ; SAMPLES ; PCR
英文摘要:

BackgroundCytomegalovirus (CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is difficult to diagnose. We aimed to evaluate the sensitivity and specificity of the detection of CMV DNA in feces for predicting CMV enteritis.

MethodsHSCT patients with intestinal graft-versus-host disease (GVHD) were enrolled if they met the following criteria: (i) underwent a colonoscopy and (ii) peripheral blood and feces specimens were available for CMV DNA detection within 24h of colonoscopy. The colonoscopy histology was used as the gold standard for diagnosing CMV enteritis.

ResultsFifty-six patients underwent 58 colonoscopy examinations, and 7 were diagnosed as having CMV enteritis. Within 24h of colonoscopy, 9 patients had detectable CMV in the feces and 19 patients had detectable CMV in the plasma, respectively. In the 7 patients with CMV enteritis, only 2 had detectable CMV in the stool, resulting in a sensitivity of 28.6%. In the 51 patients without CMV enteritis, 44 had no detectable CMV in the stool, with a specificity of 86.3%.

ConclusionWe concluded that CMV detection in the feces was not a good predictor of CMV enteritis in patients with intestinal GVHD after allo-HSCT.

语种: 英语
所属项目编号: 2013AA020401 ; 81230013 ; 2011-4022-08
项目资助者: National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development
WOS记录号: WOS:000362597900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65011
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100871, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

Recommended Citation:
Sun, Y. -Q.,Xu, L. -P.,Han, T. -T.,et al. Detection of human cytomegalovirus (CMV) DNA in feces has limited value in predicting CMV enteritis in patients with intestinal graft-versus-host disease after allogeneic stem cell transplantation[J]. TRANSPLANT INFECTIOUS DISEASE,2015,17(5):655-661.
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