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学科主题临床医学
Detection of multiple antibodies in myasthenia gravis and its clinical significance
Wang Wei-Wei2; Hao Hong-jun1; Gao Feng1
关键词myasthenia gravis thymoma antibody
刊名CHINESE MEDICAL JOURNAL
2010-09-20
DOI10.3760/cma.j.issn.0366-6999.2010.18.011
123期:18页:2555-2558
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]RYANODINE RECEPTOR ANTIBODIES ; ACETYLCHOLINE-RECEPTOR ; AUTOANTIBODIES ; TITIN ; THYMOMA ; EPITOPES
英文摘要

Background Antibodies against acetylcholine receptor, acetylcholinesterase, ryanodine receptor and titin have been found in patients with myasthenia gravis. However, the relations between these antibodies and character of myasthenia gravis are unknown. This study aimed to detect multiple antibodies in myasthenia gravis and to investigate its clinical significance.

Methods These antibodies were detected by enzyme-linked immunoabsorbent assay in 89 cases of myasthenia gravis, 66 cases of other neurological diseases and 66 healthy controls. The incidences of antibodies were compared using the chi-square test.

Results Acetylcholine receptor, acetylcholinesterase, titin and ryanodine receptor antibodies were detected in 53.9%, 20.2%, 64.0% and 55.0% of myasthenia gravis patients respectively, higher than in patients of other neurological diseases and controls groups. The combination of the four antibodies assays provided 94.4% sensitivity and 84.0% specificity for the diagnosis of myasthenia gravis. Acetylcholinesterase antibody occurred more frequently in acetylcholine receptor antibody negative patients with adverse reactions to neostigmine test. Titin antibody provided 82.1% sensitivity and 52.5% specificity for myasthenia gravis with thymoma. Incidences of titin and of ryanodine receptor antibody were higher in late onset myasthenia gravis than in early onset myasthenia gravis. The proportion of titin antibody positive patients increased with the severity of myasthenia gravis as graded by a modified Osserman scale.

Conclusions Testing for acetylcholine receptor, acetylcholinesterase, titin and ryanodine receptor antibodies can offer a better diagnostic method for myasthenia gravis than each antibody test alone. Titin antibody combined with computed tomography was better for the diagnosis of thymoma. Titin antibody occurred most frequently in severe myasthenia gravis. Chin Med J 2010;123(18):2555-2558

语种英语
WOS记录号WOS:000282806200011
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65017
专题北京大学第一临床医学院_神经内科
作者单位1.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
2.Beijing Jishuitan Hosp, Dept Geriatr, Beijing 100035, Peoples R China
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GB/T 7714
Wang Wei-Wei,Hao Hong-jun,Gao Feng. Detection of multiple antibodies in myasthenia gravis and its clinical significance[J]. CHINESE MEDICAL JOURNAL,2010,123(18):2555-2558.
APA Wang Wei-Wei,Hao Hong-jun,&Gao Feng.(2010).Detection of multiple antibodies in myasthenia gravis and its clinical significance.CHINESE MEDICAL JOURNAL,123(18),2555-2558.
MLA Wang Wei-Wei,et al."Detection of multiple antibodies in myasthenia gravis and its clinical significance".CHINESE MEDICAL JOURNAL 123.18(2010):2555-2558.
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