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学科主题: 临床医学
题名:
Detection of multiple antibodies in myasthenia gravis and its clinical significance
作者: Wang Wei-Wei2; Hao Hong-jun1; Gao Feng1
关键词: myasthenia gravis ; thymoma ; antibody
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-09-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.18.011
卷: 123, 期:18, 页:2555-2558
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RYANODINE RECEPTOR ANTIBODIES ; ACETYLCHOLINE-RECEPTOR ; AUTOANTIBODIES ; TITIN ; THYMOMA ; EPITOPES
英文摘要:

Background Antibodies against acetylcholine receptor, acetylcholinesterase, ryanodine receptor and titin have been found in patients with myasthenia gravis. However, the relations between these antibodies and character of myasthenia gravis are unknown. This study aimed to detect multiple antibodies in myasthenia gravis and to investigate its clinical significance.

Methods These antibodies were detected by enzyme-linked immunoabsorbent assay in 89 cases of myasthenia gravis, 66 cases of other neurological diseases and 66 healthy controls. The incidences of antibodies were compared using the chi-square test.

Results Acetylcholine receptor, acetylcholinesterase, titin and ryanodine receptor antibodies were detected in 53.9%, 20.2%, 64.0% and 55.0% of myasthenia gravis patients respectively, higher than in patients of other neurological diseases and controls groups. The combination of the four antibodies assays provided 94.4% sensitivity and 84.0% specificity for the diagnosis of myasthenia gravis. Acetylcholinesterase antibody occurred more frequently in acetylcholine receptor antibody negative patients with adverse reactions to neostigmine test. Titin antibody provided 82.1% sensitivity and 52.5% specificity for myasthenia gravis with thymoma. Incidences of titin and of ryanodine receptor antibody were higher in late onset myasthenia gravis than in early onset myasthenia gravis. The proportion of titin antibody positive patients increased with the severity of myasthenia gravis as graded by a modified Osserman scale.

Conclusions Testing for acetylcholine receptor, acetylcholinesterase, titin and ryanodine receptor antibodies can offer a better diagnostic method for myasthenia gravis than each antibody test alone. Titin antibody combined with computed tomography was better for the diagnosis of thymoma. Titin antibody occurred most frequently in severe myasthenia gravis. Chin Med J 2010;123(18):2555-2558

语种: 英语
WOS记录号: WOS:000282806200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65017
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
2.Beijing Jishuitan Hosp, Dept Geriatr, Beijing 100035, Peoples R China

Recommended Citation:
Wang Wei-Wei,Hao Hong-jun,Gao Feng. Detection of multiple antibodies in myasthenia gravis and its clinical significance[J]. CHINESE MEDICAL JOURNAL,2010,123(18):2555-2558.
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