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学科主题: 基础医学
题名:
Potentiating effects of L-type Ca2+ channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system
作者: Zhao, X.; Cui, X. -Y.; Chu, Q. -P.; Chen, B. -Q.; Wang, X. -M.; Lin, Z. -B.; Li, X. -J.; Ku, B. -S.; Zhang, Y. -H.
关键词: Ca2+ channel blocker ; pentobarbital ; hypnosis ; 5-HTP ; pCPA ; serotonergic system
刊名: JOURNAL OF NEURAL TRANSMISSION
发表日期: 2006-10-01
DOI: 10.1007/s00702-005-0422-1
卷: 113, 期:10, 页:1395-1402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MICROSOMAL DRUG-METABOLISM ; CALCIUM-CHANNEL ; PARA-CHLOROPHENYLALANINE ; XENOPUS LARVAE ; T-TYPE ; SLEEP ; INHIBITION ; NIFEDIPINE ; NEURONS ; DILTIAZEM
英文摘要:

In order to elucidate the mechanism(s) behind the interactions between barbiturates and Ca2+ antagonists, the effects of three structurally diverse types of Ca2+ antagonists combined or not with 5-HT on pentobarbital-induced hypnosis in mice were investigated. The results showed that dihydropyridine derivative nifedipine (10.0 and 20.0 mg/kg, p.o.) and other types of Ca2+ antagonist, verapamil (5.0 and 10.0 mg/kg, p.o.) and diltiazem (2.5, 5.0 and 10.0 mg/kg, p.o.) increased both the sleeping time in hypnotic dosage of pentobarbital (45 mg/kg, i.p.) treated mice and the rate of sleep onset in the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.) treated mice in a dose-dependent manner, respectively, and these effects were significantly augmented by 5-hydroxytryptophan (5-HTP), the immediate precursor of 5-hydroxytryptamine (5-HT). Pretreatment with p-chlorophenylalanine (PCPA, 300 mg/kg, s.c.), an inhibitor of tryptophan hydroxylase, significantly decreased pentobarbital-induced sleeping time and nifedipine (10.0 mg/kg, p.o.), verapamil (5.0 mg/kg, p.o.) and diltiazem (2.5 mg/kg, p.o.) abolished this effect. From these results, it should be presumed that the augmentative effect of L-type Ca2+ channel blockers on pentobarbital-induced sleep may be influenced by serotonergic system.

语种: 英语
WOS记录号: WOS:000240797700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65018
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Capital Univ Med Sci, Dept Physiol, Beijing, Peoples R China

Recommended Citation:
Zhao, X.,Cui, X. -Y.,Chu, Q. -P.,et al. Potentiating effects of L-type Ca2+ channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system[J]. JOURNAL OF NEURAL TRANSMISSION,2006,113(10):1395-1402.
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