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Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3
Liu, WL; Liu, GS; Hu, DY; Qi, Y; Shan, ZL; Yang, DY; Liu, DQ; Wang, YM
关键词Wolff-Parkinson-White syndrome genetics linkage analysis
刊名CHINESE MEDICAL JOURNAL
2002-11-01
115期:11页:1733-1735
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MAPS
英文摘要

Objective Wolff-Parkinson-White syndrome (WPW)is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.

Methods Linkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.

Results Wolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5.

Conclusion The gene of Wolff-Parkinson-White syndrome is located at 7q3.

语种英语
WOS记录号WOS:000179926400028
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65019
专题北京大学第二临床医学院_心血管内科
作者单位1.Children & Wemen Hosp, Dept Pediat, Hengshui, Peoples R China
2.Beijing Univ, Peoples Hosp, Div Cardiol, Beijing 100044, Peoples R China
3.Gen Army Hosp, Div Cardiol, Beijing 100853, Peoples R China
4.Beijing Univ, Hosp 1, Cent Lab, Beijing 100044, Peoples R China
5.Suixi Cty Hosp, Div Cardiol, Anhui, Peoples R China
6.Handan Municipal Hosp, Dept Med, Handan 056000, Peoples R China
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GB/T 7714
Liu, WL,Liu, GS,Hu, DY,et al. Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3[J]. CHINESE MEDICAL JOURNAL,2002,115(11):1733-1735.
APA Liu, WL.,Liu, GS.,Hu, DY.,Qi, Y.,Shan, ZL.,...&Wang, YM.(2002).Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3.CHINESE MEDICAL JOURNAL,115(11),1733-1735.
MLA Liu, WL,et al."Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3".CHINESE MEDICAL JOURNAL 115.11(2002):1733-1735.
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