IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Effect of Ibutilide on the Canine Cardiac Conduction System
Sun, Jian Ling1; Han, Rong2; Guo, Ji Hong3; Li, Xiao Ying4; Ma, Xian Lin5; Wang, Chong Yu1
关键词Cardiology Ibutilide Canines Electrophysiological character Sinoatrial node Atrioventricular node
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2012-11-01
DOI10.1007/s12013-012-9385-7
64期:2页:161-168
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]RECTIFIER K+ CURRENT ; ATRIAL-FLUTTER ; RAPID CONVERSION ; IONIC MECHANISM ; CELLS ; FIBRILLATION ; CHANNEL
英文摘要

The objective of the study was to evaluate the effect of ibutilide on canine cardiac sinoatrial and atrioventricular nodes (AVNs). For this purpose, 18 mongrel dogs were injected intravenously with ibutilide and the changes in heart rate, sinus node recovery time, and AVN were measured. Our data show that ibutilide administration caused significant suppression of the sinus atrial node, the peak response time was 20-30 min, and the heart rate was restored to pre-drug administration level. After receiving ibutilide, 1 animal had a 5 s sinus pause, and after 5 min of ibutilide administration, 1 dog showed 2:1 atrioventricular conduction. Therefore, it was concluded that ibutilide had a suppressive effect on the sinoatrial node and AVN.

语种英语
WOS记录号WOS:000309865500014
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65022
Collection北京大学第二临床医学院_心血管内科
作者单位1.Aviat Gen Hosp, Dept Cardiol, Beijing 100012, Peoples R China
2.Xinjiang Med Univ, Affiliated Hosp 6, Dept Chinese Internal Med, Urumqi 830002, Peoples R China
3.Peking Univ, Dept Cardiol, Peoples Hosp, Electrophysiol Grp, Beijing 100871, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China
5.Beijing Jian Gong Hosp, Dept Cardiol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Sun, Jian Ling,Han, Rong,Guo, Ji Hong,et al. Effect of Ibutilide on the Canine Cardiac Conduction System[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2012,64(2):161-168.
APA Sun, Jian Ling,Han, Rong,Guo, Ji Hong,Li, Xiao Ying,Ma, Xian Lin,&Wang, Chong Yu.(2012).Effect of Ibutilide on the Canine Cardiac Conduction System.CELL BIOCHEMISTRY AND BIOPHYSICS,64(2),161-168.
MLA Sun, Jian Ling,et al."Effect of Ibutilide on the Canine Cardiac Conduction System".CELL BIOCHEMISTRY AND BIOPHYSICS 64.2(2012):161-168.
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