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学科主题: 临床医学
题名:
Influence of acute normovolaemic haemodilution on bispectral index monitoring and propofol dose requirements
作者: Dahaba, A. A.1; Rinnhofer, S.1; Wang, G.2; Xu, X.2; Liu, X. Y.2; Wu, X. M.2; Rehak, P. H.3; Metzler, H.1
关键词: bispectral index ; normovolaemic haemodilution
刊名: ACTA ANAESTHESIOLOGICA SCANDINAVICA
发表日期: 2008-07-01
DOI: 10.1111/j.1399-6576.2008.01629.x
卷: 52, 期:6, 页:815-820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology
研究领域[WOS]: Anesthesiology
关键词[WOS]: SEVERE ISOVOLEMIC ANEMIA ; COGNITIVE FUNCTION ; ANESTHESIA ; HUMANS ; TRANSFUSION ; INDUCTION ; FREQUENCY ; INFUSION ; FENTANYL ; MEMORY
英文摘要:

Background: Numerous medical and physiological conditions that might alter electroencephalography (EEG), such as hypoglycaemia, hypothermia or hypovolaemia, were shown to result in the bispectral Index (BIS) indicating an incorrect hypnotic state. Recently, acute normovolaemic haemodilution (ANH) was shown to be associated with significant impairment of cognitive functions that could alter EEG and consequently BIS monitoring, an EEG derived parameter.

Methods: In a randomised clinical study, we assessed the effect of ANH on BIS monitoring before induction and after propofol target controlled infusion (TCI) anaesthesia in 45 unmedicated patients randomly allocated to ANH with oxygen insufflation (oxygen group), ANH with air insufflation (air group), or control group.

Results: With ANH, mean BIS values briefly declined in the oxygen group (82 +/- 4) and air group (84 +/- 3) before returning to baseline values. The loss of consciousness time was significantly shorter, with fewer propofol TCI dose requirements, and BIS was significantly higher in the oxygen group (1.3 +/- 0.5 min, 2.41 +/- 0.15 mu g/ml, 73 +/- 7) and air group (1.2 +/- 0.6 min, 2.44 +/- 0.17 mu g/ml, 75 +/- 5), compared with the control group (1.7 +/- 0.4 min, 2.75 +/- 0.17 mu g/ml, 61 +/- 5), respectively. Whereas, there was no significant difference in BIS values between the oxygen group (38 +/- 7), air group (36 +/- 5) and control group (40 +/- 6) at propofol TCI 4 mu g/ml anaesthesia maintenance.

Conclusions: BIS values briefly declined with ANH before returning to baseline values before anaesthesia induction. Despite transient ANH enhancement of propofol effect during induction, there was no significant difference in BIS values with or without ANH during propofol maintenance of anaesthesia.

语种: 英语
WOS记录号: WOS:000256683700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65023
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Med Univ Graz, Dept Anaesthesiol & Intens Care Med, A-8036 Graz, Austria
2.Peking Univ, Hosp 1, Dept Anaesthesiol, Beijing 100871, Peoples R China
3.Med Univ Graz, Dept Surg, Biomed Engn & Comp Unit, A-8036 Graz, Austria

Recommended Citation:
Dahaba, A. A.,Rinnhofer, S.,Wang, G.,et al. Influence of acute normovolaemic haemodilution on bispectral index monitoring and propofol dose requirements[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA,2008,52(6):815-820.
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