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Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study
Amini, Peyvand1; Wadden, Danny1; Cahill, Farrell1; Randell, Edward2; Vasdev, Sudesh1; Chen, Xihua3; Gulliver, Wayne1; Zhang, Weizhen4; Zhang, Hongwei1; Yi, Yanqing1; Sun, Guang1
刊名PLOS ONE
2012-09-20
DOI10.1371/journal.pone.0045657
7期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]PLASMA GHRELIN ; CIRCULATING GHRELIN ; METABOLIC SYNDROME ; DIABETES-MELLITUS ; HUMANS ; GLUCOSE ; SENSITIVITY ; SECRETION ; HOMEOSTASIS ; PREVALENCE
英文摘要

Objective: Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study.

Design: A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjects were assessed. Subjects were of at least third generation Newfoundland descent, between the ages of 20 and 79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method. Insulin and fasting glucose were measured by Immulite 2500 autoanalyzer and Lx20 clinical chemistry analyzer, respectively. Homeostatic Model Assessment of beta cell function (HOMA-beta) and Insulin Resistance (HOMA-IR) and Quantitative Insulin-sensitivity Check Index (QUICKI) were used for measurement of insulin resistance.

Results: Partial correlation analyses showed a significant negative correlation between circulating ghrelin and insulin level and insulin resistance in the entire cohort and also in men and women separately. The aforementioned correlation was independent of age, percentage of trunk fat and HDL-cholesterol. According to menopausal status, only pre-menopausal women revealed negative correlations.

Conclusion: Our results suggest that except for postmenopausal women, high circulating ghrelin level is associated with lower insulin resistance in the general population.

语种英语
WOS记录号WOS:000309388900087
项目编号MOP192552
资助机构Canadian Institutes for Health Research (CIHR)
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65025
专题北京大学基础医学院
作者单位1.Mem Univ Newfoundland, Div Med, St John, NF, Canada
2.Mem Univ Newfoundland, Discipline Lab Med, St John, NF, Canada
3.Mem Univ Newfoundland, Div Biomed Sci, St John, NF, Canada
4.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Amini, Peyvand,Wadden, Danny,Cahill, Farrell,et al. Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study[J]. PLOS ONE,2012,7(9).
APA Amini, Peyvand.,Wadden, Danny.,Cahill, Farrell.,Randell, Edward.,Vasdev, Sudesh.,...&Sun, Guang.(2012).Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study.PLOS ONE,7(9).
MLA Amini, Peyvand,et al."Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study".PLOS ONE 7.9(2012).
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