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学科主题: 基础医学
题名:
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study
作者: Amini, Peyvand1; Wadden, Danny1; Cahill, Farrell1; Randell, Edward2; Vasdev, Sudesh1; Chen, Xihua3; Gulliver, Wayne1; Zhang, Weizhen4; Zhang, Hongwei1; Yi, Yanqing1; Sun, Guang1
刊名: PLOS ONE
发表日期: 2012-09-20
DOI: 10.1371/journal.pone.0045657
卷: 7, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PLASMA GHRELIN ; CIRCULATING GHRELIN ; METABOLIC SYNDROME ; DIABETES-MELLITUS ; HUMANS ; GLUCOSE ; SENSITIVITY ; SECRETION ; HOMEOSTASIS ; PREVALENCE
英文摘要:

Objective: Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study.

Design: A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjects were assessed. Subjects were of at least third generation Newfoundland descent, between the ages of 20 and 79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method. Insulin and fasting glucose were measured by Immulite 2500 autoanalyzer and Lx20 clinical chemistry analyzer, respectively. Homeostatic Model Assessment of beta cell function (HOMA-beta) and Insulin Resistance (HOMA-IR) and Quantitative Insulin-sensitivity Check Index (QUICKI) were used for measurement of insulin resistance.

Results: Partial correlation analyses showed a significant negative correlation between circulating ghrelin and insulin level and insulin resistance in the entire cohort and also in men and women separately. The aforementioned correlation was independent of age, percentage of trunk fat and HDL-cholesterol. According to menopausal status, only pre-menopausal women revealed negative correlations.

Conclusion: Our results suggest that except for postmenopausal women, high circulating ghrelin level is associated with lower insulin resistance in the general population.

语种: 英语
所属项目编号: MOP192552
项目资助者: Canadian Institutes for Health Research (CIHR)
WOS记录号: WOS:000309388900087
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65025
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Mem Univ Newfoundland, Div Med, St John, NF, Canada
2.Mem Univ Newfoundland, Discipline Lab Med, St John, NF, Canada
3.Mem Univ Newfoundland, Div Biomed Sci, St John, NF, Canada
4.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Amini, Peyvand,Wadden, Danny,Cahill, Farrell,et al. Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study[J]. PLOS ONE,2012,7(9).
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