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学科主题: 临床医学
题名:
Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation
作者: Han, Jiangli1,2; Cheng, Jie1; Mathuria, Nilesh1
关键词: Atrial fibrillation ; new technology ; pharmacology
刊名: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
发表日期: 2012-07-01
DOI: 10.1111/j.1540-8159.2012.03367.x
卷: 35, 期:7, 页:887-896
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Engineering, Biomedical
研究领域[WOS]: Cardiovascular System & Cardiology ; Engineering
关键词[WOS]: APPENDAGE TRANSCATHETER OCCLUSION ; FACTOR-XA INHIBITOR ; PULMONARY VEIN ISOLATION ; ORAL DIRECT THROMBIN ; WARFARIN THERAPY ; HIGH-RISK ; ANTICOAGULATION ; ASPIRIN ; CLOSURE ; TRIALS
英文摘要:

Thromboembolism is the crucial cause of ischemic stroke in patients with atrial fibrillation (AF). Anticoagulation therapy with vitamin K antagonists, such as warfarin, have been proven to be effective for stroke prevention in AF. Nonetheless, the use of warfarin may be limited due to increased risk of bleeding, the potential interaction with multiple foods and drugs, and the need for routine coagulation monitoring. Over the last decade anticoagulants, such as dabigatran and rivaroxaban, have been developed and have shown superiority compared to warfarin for preventing stroke in patients with nonvalvular AF in large randomized trials. In addition, on account of the risk of thrombus formation in the left atrial appendage (LAA), many nonpharmacologic approaches have been developed to reduce stroke risk in patients with AF who are not candidates for anticoagulant therapy. Surgical, epicardial, and endovascular techniques for LAA closure are being investigated currently. Both novel pharmacotherapy and nonpharmacologic approaches for stroke prevention will be detailed in this review. (PACE 2012;XX:111)

语种: 英语
WOS记录号: WOS:000305897500032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65027
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA

Recommended Citation:
Han, Jiangli,Cheng, Jie,Mathuria, Nilesh. Pharmacologic and Nonpharmacologic Therapies for Stroke Prevention in Nonvalvular Atrial Fibrillation[J]. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY,2012,35(7):887-896.
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