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学科主题临床医学
Microneedle pretreatment improves efficacy of cutaneous topical anesthesia
Li, Xiaoguang2,3; Zhao, Rongsheng2,3; Qin, Zelian2,3; Zhang, Jie2,3; Zhai, Suodi2,3; Qiu, Yuqin4; Gao, Yunhua4; Xu, Bai4,5; Thomas, Stephen H.1
刊名AMERICAN JOURNAL OF EMERGENCY MEDICINE
2010-02-01
DOI10.1016/j.ajem.2008.10.001
28期:2页:130-134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Emergency Medicine
研究领域[WOS]Emergency Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; VISUAL ANALOG SCALE/ ; INTRAVENOUS INSERTION ; ELA-MAX ; PAIN ; CHILDREN ; LIDOCAINE ; EMLA ; VENIPUNCTURE ; PLACEMENT
英文摘要

Methods to facilitate topical anesthesia for venipuncture are characterized by substantial limitations. This randomized double-blind study was undertaken to assess whether use of a quickly and painlessly applied microneedle system (functional microarray, FMA) to create punctures in the stratum corneum facilitates topical anesthesia in healthy adults. In 25 volunteers receiving topical dyclonine, FMA was applied to one forearm) and a sham device in the other, followed by assessment of pain levels associated with application of a standardized stimulus at 5-minute intervals over an hour. Analysis of the primary end point, time required to achieve a significant degree of pain reduction (13 mm on a 100-mm scale), revealed that FMA significantly sped time to pain reduction (log-rank P=.007). Functional microarray also resulted in a greater degree of pain reduction (Kruskal-Wallis P<.0001). Functional microarray application had no adverse effects, and the device shows promise for facilitation of topical anesthesia. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000278672000002
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65035
专题北京大学第三临床医学院_药剂科
北京大学第三临床医学院_成形外科
作者单位1.Dept Emergency Serv, Boston, MA USA
2.Peking Univ, Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Dept Plast Surg, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
5.Suzhou Natong Nanobiotechnol Ltd, Suzhou 215123, Peoples R China
推荐引用方式
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Li, Xiaoguang,Zhao, Rongsheng,Qin, Zelian,et al. Microneedle pretreatment improves efficacy of cutaneous topical anesthesia[J]. AMERICAN JOURNAL OF EMERGENCY MEDICINE,2010,28(2):130-134.
APA Li, Xiaoguang.,Zhao, Rongsheng.,Qin, Zelian.,Zhang, Jie.,Zhai, Suodi.,...&Thomas, Stephen H..(2010).Microneedle pretreatment improves efficacy of cutaneous topical anesthesia.AMERICAN JOURNAL OF EMERGENCY MEDICINE,28(2),130-134.
MLA Li, Xiaoguang,et al."Microneedle pretreatment improves efficacy of cutaneous topical anesthesia".AMERICAN JOURNAL OF EMERGENCY MEDICINE 28.2(2010):130-134.
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