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学科主题: 临床医学
题名:
Microneedle pretreatment improves efficacy of cutaneous topical anesthesia
作者: Li, Xiaoguang2,3; Zhao, Rongsheng2,3; Qin, Zelian2,3; Zhang, Jie2,3; Zhai, Suodi2,3; Qiu, Yuqin4; Gao, Yunhua4; Xu, Bai4,5; Thomas, Stephen H.1
刊名: AMERICAN JOURNAL OF EMERGENCY MEDICINE
发表日期: 2010-02-01
DOI: 10.1016/j.ajem.2008.10.001
卷: 28, 期:2, 页:130-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Emergency Medicine
研究领域[WOS]: Emergency Medicine
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; VISUAL ANALOG SCALE/ ; INTRAVENOUS INSERTION ; ELA-MAX ; PAIN ; CHILDREN ; LIDOCAINE ; EMLA ; VENIPUNCTURE ; PLACEMENT
英文摘要:

Methods to facilitate topical anesthesia for venipuncture are characterized by substantial limitations. This randomized double-blind study was undertaken to assess whether use of a quickly and painlessly applied microneedle system (functional microarray, FMA) to create punctures in the stratum corneum facilitates topical anesthesia in healthy adults. In 25 volunteers receiving topical dyclonine, FMA was applied to one forearm) and a sham device in the other, followed by assessment of pain levels associated with application of a standardized stimulus at 5-minute intervals over an hour. Analysis of the primary end point, time required to achieve a significant degree of pain reduction (13 mm on a 100-mm scale), revealed that FMA significantly sped time to pain reduction (log-rank P=.007). Functional microarray also resulted in a greater degree of pain reduction (Kruskal-Wallis P<.0001). Functional microarray application had no adverse effects, and the device shows promise for facilitation of topical anesthesia. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000278672000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65035
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Dept Emergency Serv, Boston, MA USA
2.Peking Univ, Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Dept Plast Surg, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
5.Suzhou Natong Nanobiotechnol Ltd, Suzhou 215123, Peoples R China

Recommended Citation:
Li, Xiaoguang,Zhao, Rongsheng,Qin, Zelian,et al. Microneedle pretreatment improves efficacy of cutaneous topical anesthesia[J]. AMERICAN JOURNAL OF EMERGENCY MEDICINE,2010,28(2):130-134.
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