|Long-term risk of late and very late stent thrombosis in patients treated with everolimus against paclitaxel-eluting stents: an updated meta-analysis|
|Li, Peng1; Liu, Jun-Peng2|
|关键词||diabetes everolimus-eluting stent major adverse cardiac event paclitaxel-eluting stent very late stent thrombosis|
|刊名||CORONARY ARTERY DISEASE|
|WOS标题词||Science & Technology|
|类目[WOS]||Peripheral Vascular Disease|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||CORONARY-ARTERY-DISEASE ; COMPREHENSIVE NETWORK METAANALYSIS ; BARE-METAL STENTS ; XIENCE V ; FOLLOW-UP ; CLINICAL-EVALUATION ; TRIAL ; OUTCOMES ; INTERVENTION ; SYSTEM|
Objectives Everolimus-eluting stent (EES) reduces the risk of late and very late stent thrombosis (ST) in a number of randomized controlled trials (RCTs). However, the benefits have been variable.
Materials and methods We evaluated the effect of EES and paclitaxel-eluting stent (PES) on the risk of late and very late ST in patients with coronary artery disease.
Results We identified RCTs by a systematic search of MEDLINE, EMBASE, and Cochrane Database. Seven RCTs (8162 patients) were included. Overall, EES therapy lowered the risk of very late ST significantly [relative risk (RR), 0.40; 95% confidence interval (CI), 0.20-0.80; I-2 = 0.0%; P = 0.009] compared with PES. Meanwhile, EES was associated with a significantly lower incidence of major adverse cardiac events (RR, 0.76; 95% CI, 0.67-0.86; I-2 = 34.2%; P = 0.00) driven by a markedly lower rate of myocardial infarction and target-vessel revascularization in the EES group. However, there was no significant difference in the risk of late ST (RR, 0.45; 95% CI, 0.15-1.39; I-2 = 30.7%; P = 0.166) between the two groups. A subgroup analysis showed that EES might not decrease the risk of very late ST significantly in patients older than 63.5 years or in patients with diabetes, those presenting with acute coronary syndrome, or those with a longer follow-up.
Conclusion Compared with PES, EES treatment decreased risk of very late ST significantly. However, the risk of late ST was similar between the two groups. More studies are needed to confirm the subgroup findings. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
|作者单位||1.Beijing Hosp, Dept Cardiol, Beijing 100730, Peoples R China|
2.Peking Univ, Shougang Hosp, Dept ICU, Beijing 100871, Peoples R China
|Li, Peng,Liu, Jun-Peng. Long-term risk of late and very late stent thrombosis in patients treated with everolimus against paclitaxel-eluting stents: an updated meta-analysis[J]. CORONARY ARTERY DISEASE,2014,25(5):369-377.|
|APA||Li, Peng,&Liu, Jun-Peng.(2014).Long-term risk of late and very late stent thrombosis in patients treated with everolimus against paclitaxel-eluting stents: an updated meta-analysis.CORONARY ARTERY DISEASE,25(5),369-377.|
|MLA||Li, Peng,et al."Long-term risk of late and very late stent thrombosis in patients treated with everolimus against paclitaxel-eluting stents: an updated meta-analysis".CORONARY ARTERY DISEASE 25.5(2014):369-377.|