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学科主题: 药物依赖
题名:
Green tea polyphenols produce antidepressant-like effects in adult mice
作者: Zhu, Wei-Li1; Shi, Hai-Shui1,2; Wei, Yi-Ming3; Wang, Shen-Jun1; Sun, Cheng-Yu1; Ding, Zeng-Bo1; Lu, Lin1
关键词: Green tea polyphenols ; Antidepressant ; Corticosterone ; Adrenocorticotropic hormone ; Hypothalamic-pituitary-adrenal axis
刊名: PHARMACOLOGICAL RESEARCH
发表日期: 2012
DOI: 10.1016/j.phrs.2011.09.007
卷: 65, 期:1, 页:74-80
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HIPPOCAMPAL NEUROGENESIS ; ALZHEIMERS-DISEASE ; MAJOR DEPRESSION ; BIPOLAR DISORDER ; OXIDATIVE STRESS ; DENTATE GYRUS ; ANIMAL-MODEL ; HUMAN HEALTH ; ANTIOXIDANTS ; METABOLITES
英文摘要:

Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like effects and the possible mechanism of action of green tea in widely used mouse models of depression. Mice were orally administered green tea polyphenols (GTP; 5.10 and 20 mg/kg) for 7 days and assessed in the forced swimming test (FST) and tail suspension test (TST) 60 min after the last GTP administration. Serum corticosterone and adrenocorticotrophic hormone (ACTH) levels were also determined immediately after the FST. Green tea polyphenols significantly reduced immobility in both the FST and TST but did not alter locomotor activity in the open field test, suggesting that GTP has antidepressant-like effects, and this action did not induce nonspecific motor changes in mice. Green tea polyphenols also reduced serum corticosterone and ACTH levels in mice exposed to the FST. The present study demonstrated that GTP exerts antidepressant-like effects in a mouse behavioral models of depression, and the mechanism may involve inhibition of the hypothalamic-pituitary-adrenal axis. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30800362 ; 2007CB512302 ; 2009CB522004 ; 2010J01174
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ; Natural Science Foundation of Fujian Province
WOS记录号: WOS:000301868200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65045
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China
3.Fujian Med Univ, Dept Basic Med, Fuzhou 350108, Peoples R China

Recommended Citation:
Zhu, Wei-Li,Shi, Hai-Shui,Wei, Yi-Ming,et al. Green tea polyphenols produce antidepressant-like effects in adult mice[J]. PHARMACOLOGICAL RESEARCH,2012,65(1):74-80.
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