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Green tea polyphenols produce antidepressant-like effects in adult mice
Zhu, Wei-Li1; Shi, Hai-Shui1,2; Wei, Yi-Ming3; Wang, Shen-Jun1; Sun, Cheng-Yu1; Ding, Zeng-Bo1; Lu, Lin1
关键词Green tea polyphenols Antidepressant Corticosterone Adrenocorticotropic hormone Hypothalamic-pituitary-adrenal axis
刊名PHARMACOLOGICAL RESEARCH
2012
DOI10.1016/j.phrs.2011.09.007
65期:1页:74-80
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HIPPOCAMPAL NEUROGENESIS ; ALZHEIMERS-DISEASE ; MAJOR DEPRESSION ; BIPOLAR DISORDER ; OXIDATIVE STRESS ; DENTATE GYRUS ; ANIMAL-MODEL ; HUMAN HEALTH ; ANTIOXIDANTS ; METABOLITES
英文摘要

Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like effects and the possible mechanism of action of green tea in widely used mouse models of depression. Mice were orally administered green tea polyphenols (GTP; 5.10 and 20 mg/kg) for 7 days and assessed in the forced swimming test (FST) and tail suspension test (TST) 60 min after the last GTP administration. Serum corticosterone and adrenocorticotrophic hormone (ACTH) levels were also determined immediately after the FST. Green tea polyphenols significantly reduced immobility in both the FST and TST but did not alter locomotor activity in the open field test, suggesting that GTP has antidepressant-like effects, and this action did not induce nonspecific motor changes in mice. Green tea polyphenols also reduced serum corticosterone and ACTH levels in mice exposed to the FST. The present study demonstrated that GTP exerts antidepressant-like effects in a mouse behavioral models of depression, and the mechanism may involve inhibition of the hypothalamic-pituitary-adrenal axis. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000301868200010
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65045
专题北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China
3.Fujian Med Univ, Dept Basic Med, Fuzhou 350108, Peoples R China
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GB/T 7714
Zhu, Wei-Li,Shi, Hai-Shui,Wei, Yi-Ming,et al. Green tea polyphenols produce antidepressant-like effects in adult mice[J]. PHARMACOLOGICAL RESEARCH,2012,65(1):74-80.
APA Zhu, Wei-Li.,Shi, Hai-Shui.,Wei, Yi-Ming.,Wang, Shen-Jun.,Sun, Cheng-Yu.,...&Lu, Lin.(2012).Green tea polyphenols produce antidepressant-like effects in adult mice.PHARMACOLOGICAL RESEARCH,65(1),74-80.
MLA Zhu, Wei-Li,et al."Green tea polyphenols produce antidepressant-like effects in adult mice".PHARMACOLOGICAL RESEARCH 65.1(2012):74-80.
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