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Developmental toxicity research of ginsenoside Rb1 using a whole mouse embryo culture model
Liu, P; Xu, YJ; Yin, HJ; Wang, JB; Chen, KJ; Li, Y
关键词developmental toxicity ginseng ginsenoside Rb1 whole mouse embryo culture
刊名BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
2005-04-01
DOI10.1002/bdrb.20038
74期:2页:207-209
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Genetics & Heredity ; Toxicology
研究领域[WOS]Oncology ; Genetics & Heredity ; Toxicology
关键词[WOS]PANAX-GINSENG ; PHARMACOLOGY
英文摘要

BACKGROUND: Ginseng has been widely used around the world for many years. Knowledge is limited, however, on its effects on embryortic development. METHODS: Whole embryo culture was used to explore the developmental toxicity of ginsenoside Rb1 (GRb1) on mouse embryos. All embryos were exposed to different concentrations of GRb1, and scored for their growth and differentiation at the end of the 48-hr culture period. RESULTS: Total morphological score decreased significantly at the concentration of GRb1 of 30 mu g/ml and was further reduced at 50 mu g/ml. Yolk sac was affected at the lower concentration of 15 mu g/ml. Developments of midbrain, forebrain, and optic system were relatively sensitive to GRb1 and were affected at the concentration of 30 mu g/ml. Allantois, flexion, branchial arch, and limb buds were affected at 50 mu g/ml. At this concentration, the embryonic crown-rump length, head length, and somite number were also reduced significantly compared to the control group. CONCLUSIONS: These results suggest that GRb1 has teratogenic effect during the mouse organogenetic period. We suggest that before more data in humans is available, ginseng should be used with caution by pregnant women in the first trimester. (c) 2005 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000228799200008
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65046
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
2.Acad Tradit Chinese Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, P,Xu, YJ,Yin, HJ,et al. Developmental toxicity research of ginsenoside Rb1 using a whole mouse embryo culture model[J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,2005,74(2):207-209.
APA Liu, P,Xu, YJ,Yin, HJ,Wang, JB,Chen, KJ,&Li, Y.(2005).Developmental toxicity research of ginsenoside Rb1 using a whole mouse embryo culture model.BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY,74(2),207-209.
MLA Liu, P,et al."Developmental toxicity research of ginsenoside Rb1 using a whole mouse embryo culture model".BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 74.2(2005):207-209.
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