IR@PKUHSC  > 北京大学药学院
学科主题药学
Design and synthesis of new KRN7000 analogues
Sun, Man; Wang, Yuhang; Ye, Xin-Shan
关键词KRN7000 analogue Glycolipid alpha-GalCer Carbohydrate Synthesis
刊名TETRAHEDRON
2013-09-02
DOI10.1016/j.tet.2013.06.051
69期:35页:7438-7447
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]KILLER T-CELLS ; POT OLIGOSACCHARIDE SYNTHESIS ; SPONGE AGELAS-MAURITIANUS ; NKT CELLS ; ALPHA-GALACTOSYLCERAMIDES ; INKT CELLS ; EFFICIENT SYNTHESIS ; IMMUNE-SYSTEM ; GLYCOLIPIDS ; CERAMIDE
英文摘要

Presented by CD1d protein, KRN7000, a potent synthetic cc-galactosylceramide, is known to stimulate the iNKT cells to produce different bioactive cytokines. Six new KRN7000 analogues, in which the amide bond in KRN7000 is replaced with O, NH, or ester groups incorporating variation of the acyl chain, or possessing an additional four-atom linker between the galactose and phytosphingosine moiety, were designed and synthesized. The synthetic compounds were evaluated for their ability to stimulate cytokine release and the preliminary structure activity relationships were discussed. The synthetic strategy will benefit the construction of more KRN7000 derivatives, which may contribute to cytokine profile bias. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000322557500033
项目编号21232002 ; 2012CB822100
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65047
专题北京大学药学院
北京大学药学院_药物化学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Man,Wang, Yuhang,Ye, Xin-Shan. Design and synthesis of new KRN7000 analogues[J]. TETRAHEDRON,2013,69(35):7438-7447.
APA Sun, Man,Wang, Yuhang,&Ye, Xin-Shan.(2013).Design and synthesis of new KRN7000 analogues.TETRAHEDRON,69(35),7438-7447.
MLA Sun, Man,et al."Design and synthesis of new KRN7000 analogues".TETRAHEDRON 69.35(2013):7438-7447.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun, Man]的文章
[Wang, Yuhang]的文章
[Ye, Xin-Shan]的文章
百度学术
百度学术中相似的文章
[Sun, Man]的文章
[Wang, Yuhang]的文章
[Ye, Xin-Shan]的文章
必应学术
必应学术中相似的文章
[Sun, Man]的文章
[Wang, Yuhang]的文章
[Ye, Xin-Shan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。