北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Design and synthesis of new KRN7000 analogues
作者: Sun, Man; Wang, Yuhang; Ye, Xin-Shan
关键词: KRN7000 analogue ; Glycolipid ; alpha-GalCer ; Carbohydrate ; Synthesis
刊名: TETRAHEDRON
发表日期: 2013-09-02
DOI: 10.1016/j.tet.2013.06.051
卷: 69, 期:35, 页:7438-7447
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: KILLER T-CELLS ; POT OLIGOSACCHARIDE SYNTHESIS ; SPONGE AGELAS-MAURITIANUS ; NKT CELLS ; ALPHA-GALACTOSYLCERAMIDES ; INKT CELLS ; EFFICIENT SYNTHESIS ; IMMUNE-SYSTEM ; GLYCOLIPIDS ; CERAMIDE
英文摘要:

Presented by CD1d protein, KRN7000, a potent synthetic cc-galactosylceramide, is known to stimulate the iNKT cells to produce different bioactive cytokines. Six new KRN7000 analogues, in which the amide bond in KRN7000 is replaced with O, NH, or ester groups incorporating variation of the acyl chain, or possessing an additional four-atom linker between the galactose and phytosphingosine moiety, were designed and synthesized. The synthetic compounds were evaluated for their ability to stimulate cytokine release and the preliminary structure activity relationships were discussed. The synthetic strategy will benefit the construction of more KRN7000 derivatives, which may contribute to cytokine profile bias. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21232002 ; 2012CB822100
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000322557500033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65047
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Man,Wang, Yuhang,Ye, Xin-Shan. Design and synthesis of new KRN7000 analogues[J]. TETRAHEDRON,2013,69(35):7438-7447.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Man]'s Articles
[Wang, Yuhang]'s Articles
[Ye, Xin-Shan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Man]‘s Articles
[Wang, Yuhang]‘s Articles
[Ye, Xin-Shan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace