|Risk factors for the development of vaginal intraepithelial neoplasia|
|Li Hua1; Guo Yan-li1; Zhang Jing-xu2; Qiao Jie1; Geng Li1|
|关键词||vaginal intraepithelial neoplasia vaginal intraepithelial neoplasia risk factor human papillomavirus cervical intraepithelial neoplasia|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||HUMAN-PAPILLOMAVIRUS ; CERVICAL-CANCER ; VIRAL LOAD ; WOMEN ; RECURRENCE ; CARCINOMA ; AGE|
Background Vaginal intraepithelial neoplasia (VAIN), as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population.
Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus (HPV) status.
Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women (95% Cl: 1.10-3.85; P=0.024). The patients with previous hysterectomy had an increased risk of VAIN (OR=4.69; P=0.003). Patients with a history of cervical cancer or CIN were predisposed to VAIN (OR=78.75; P <0.0001). The: rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load (OR=126.00; P=0.000). Multivariate analysis showed that HPV infection and a history of GIN or cervical cancer were still found to be significant in patients.
Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN. Chin Med J 2012;125(7):1219-1223
|项目编号||11072006 ; 2009B03|
|资助机构||National Natural Science Foundation of China ; Beijing Nova Program|
|作者单位||1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China|
2.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100191, Peoples R China
|Li Hua,Guo Yan-li,Zhang Jing-xu,et al. Risk factors for the development of vaginal intraepithelial neoplasia[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1219-1223.|
|APA||Li Hua,Guo Yan-li,Zhang Jing-xu,Qiao Jie,&Geng Li.(2012).Risk factors for the development of vaginal intraepithelial neoplasia.CHINESE MEDICAL JOURNAL,125(7),1219-1223.|
|MLA||Li Hua,et al."Risk factors for the development of vaginal intraepithelial neoplasia".CHINESE MEDICAL JOURNAL 125.7(2012):1219-1223.|