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学科主题: 临床医学
题名:
Risk factors for the development of vaginal intraepithelial neoplasia
作者: Li Hua1; Guo Yan-li1; Zhang Jing-xu2; Qiao Jie1; Geng Li1
关键词: vaginal intraepithelial neoplasia ; vaginal intraepithelial neoplasia ; risk factor ; human papillomavirus ; cervical intraepithelial neoplasia
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-04-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.07.006
卷: 125, 期:7, 页:1219-1223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HUMAN-PAPILLOMAVIRUS ; CERVICAL-CANCER ; VIRAL LOAD ; WOMEN ; RECURRENCE ; CARCINOMA ; AGE
英文摘要:

Background Vaginal intraepithelial neoplasia (VAIN), as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population.

Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus (HPV) status.

Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women (95% Cl: 1.10-3.85; P=0.024). The patients with previous hysterectomy had an increased risk of VAIN (OR=4.69; P=0.003). Patients with a history of cervical cancer or CIN were predisposed to VAIN (OR=78.75; P <0.0001). The: rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load (OR=126.00; P=0.000). Multivariate analysis showed that HPV infection and a history of GIN or cervical cancer were still found to be significant in patients.

Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN. Chin Med J 2012;125(7):1219-1223

语种: 英语
所属项目编号: 11072006 ; 2009B03
项目资助者: National Natural Science Foundation of China ; Beijing Nova Program
WOS记录号: WOS:000302882600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65049
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Li Hua,Guo Yan-li,Zhang Jing-xu,et al. Risk factors for the development of vaginal intraepithelial neoplasia[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1219-1223.
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