IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Risk factors for the development of vaginal intraepithelial neoplasia
Li Hua1; Guo Yan-li1; Zhang Jing-xu2; Qiao Jie1; Geng Li1
关键词vaginal intraepithelial neoplasia vaginal intraepithelial neoplasia risk factor human papillomavirus cervical intraepithelial neoplasia
刊名CHINESE MEDICAL JOURNAL
2012-04-05
DOI10.3760/cma.j.issn.0366-6999.2012.07.006
125期:7页:1219-1223
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]HUMAN-PAPILLOMAVIRUS ; CERVICAL-CANCER ; VIRAL LOAD ; WOMEN ; RECURRENCE ; CARCINOMA ; AGE
英文摘要

Background Vaginal intraepithelial neoplasia (VAIN), as a precursor of vaginal cancer, is a rare disease. Its prevalence has not been well analyzed. This research is to ascertain the risk factors for VAIN in a Chinese population.

Methods A case-control study was conducted, including 63 VAIN cases and 64healthy controls. In all subjects Pap smear and HPV tests were performed. A questionnaire survey was distributed, covering information on socio-demographic characteristics, smoking, past history, reproductive and sexual histories. The clinical pathological data were collected from medical records including symptoms, Pap smear results, grade of lesions, and human papillomavirus (HPV) status.

Results Postmenopausal women had a 2.09 times higher risk for VAIN than pre-menopausal women (95% Cl: 1.10-3.85; P=0.024). The patients with previous hysterectomy had an increased risk of VAIN (OR=4.69; P=0.003). Patients with a history of cervical cancer or CIN were predisposed to VAIN (OR=78.75; P <0.0001). The: rate of HPV infection in VAIN was significantly higher than in controls, and an increased risk of VAIN was observed in patients with higher viral load (OR=126.00; P=0.000). Multivariate analysis showed that HPV infection and a history of GIN or cervical cancer were still found to be significant in patients.

Conclusion HPV infection and a history of CIN or cervical cancer are the main risk factors for the development of VAIN. Chin Med J 2012;125(7):1219-1223

语种英语
WOS记录号WOS:000302882600006
项目编号11072006 ; 2009B03
资助机构National Natural Science Foundation of China ; Beijing Nova Program
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65049
专题北京大学第三临床医学院
北京大学公共卫生学院_妇女与儿童青少年卫生学系
北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
北京大学第一临床医学院_呼吸科
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li Hua,Guo Yan-li,Zhang Jing-xu,et al. Risk factors for the development of vaginal intraepithelial neoplasia[J]. CHINESE MEDICAL JOURNAL,2012,125(7):1219-1223.
APA Li Hua,Guo Yan-li,Zhang Jing-xu,Qiao Jie,&Geng Li.(2012).Risk factors for the development of vaginal intraepithelial neoplasia.CHINESE MEDICAL JOURNAL,125(7),1219-1223.
MLA Li Hua,et al."Risk factors for the development of vaginal intraepithelial neoplasia".CHINESE MEDICAL JOURNAL 125.7(2012):1219-1223.
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