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Anterior Segment Neovascularization in Diabetic Retinopathy: A Masquerade
Cheng, Yong1,2,3; Qu, Jinfeng1,2,3; Chen, Yi1,2,3; Zhao, Mingwei1,2,3; Li, Xiaoxin1,2,3
刊名PLOS ONE
2015-06-01
DOI10.1371/journal.pone.0123627
10期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OCULAR ISCHEMIC SYNDROME ; CAROTID-ENDARTERECTOMY ; BLOOD-FLOW ; ARTERY ; CIRCULATION ; STENOSIS ; DISEASE ; ORBIT ; EYE
英文摘要

Purpose

Anterior segment neovascularization (ASNV) could be a masquerade for ocular ischemic syndrome (OIS) in diabetic patients which misleads diagnosis and treatment. The purpose of our study is to find the relationship between blood flow velocity in carotid siphon and the development of ASNV in diabetic.

Methods

We reviewed 34 eyes of 17 diabetic patients who had Transcranial Color Doppler (TCD) examination with unilateral ASNV. The circulatory parameters of both eyes of each patient were compared and analyzed. In addition, 9 patients with more than 50% stenosis of extracranial internal carotid artery (ICA) and low velocity flow through TCD had been treated by carotid revascularization surgery.

Results

The maximal velocity in systole (Vmax) of carotid siphon (SCA) was lower in the eyes with ASNV than in the eyes without ASNV (P<0.05). ASNV of all the 9 patients regressed totally and BCVA improved significantly (P<0.05). Stenosis of ICA and arm-retina time (ART) decreased significantly (P<0.01) and SCA and ophthalmic artery (OA) increased significantly (P<0.01).

Conclusions

Our study showed ASNV could be a masquerade for OIS in patients with diabetic retinopathy. The decreased blood flow velocity in carotid siphon is related to the development of ASNV. Circulatory parameters screening of SCA by TCD is important to help us to evaluate the blood flow in SCA, the possibility of development of ASNV, and the prognosis of the patient. Interference such as carotid endarterectomy (CEA) or carotid artery stenting (CAS) can be performed if necessary to improve the blood flow in SCA and make ASNV regression.

语种英语
WOS记录号WOS:000356630900008
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65056
专题北京大学第二临床医学院_眼科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
2.Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cheng, Yong,Qu, Jinfeng,Chen, Yi,et al. Anterior Segment Neovascularization in Diabetic Retinopathy: A Masquerade[J]. PLOS ONE,2015,10(6).
APA Cheng, Yong,Qu, Jinfeng,Chen, Yi,Zhao, Mingwei,&Li, Xiaoxin.(2015).Anterior Segment Neovascularization in Diabetic Retinopathy: A Masquerade.PLOS ONE,10(6).
MLA Cheng, Yong,et al."Anterior Segment Neovascularization in Diabetic Retinopathy: A Masquerade".PLOS ONE 10.6(2015).
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