学科主题临床医学
2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication
Ma, Hui; Zhao, Xing-Liang; Wang, Xue-Yan; Xie, Xing-Wang; Han, Jin-Chao; Guan, Wen-Li; Wang, Qin; Zhu, Lin; Pan, Xiao-Ben; Wei, Lai
刊名PLOS ONE
2013-11-18
DOI10.1371/journal.pone.0080769
8期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]N-TERMINAL DOMAIN ; MEMBRANE ANCHOR ; GENE-EXPRESSION ; TRANSGENIC MICE ; C VIRUS ; INTERFERON ; PROTEIN ; SIGNAL ; CELLS ; IDENTIFICATION
英文摘要

2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) is a member of the interferon-stimulated genes, which includes isoforms CNP1 and CNP2. CNP1 is locally expressed in the myelin sheath but CNP2 is additionally expressed at low levels outside the nervous system. CNPs regulate multiple cellular functions and suppress protein production by association with polyadenylation of mRNA. Polyadenylation of Hepatitis B virus (HBV) RNAs is crucial for HBV replication. Whether CNPs interact with polyadenylation signal of HBV RNAs and interfere HBV replication is unknown. In this study, we evaluated expressions of CNP isoforms in hepatoma cell lines and their effects on HBV replication. We found that CNP2 is moderately expressed and gently responded to interferon treatment in HepG2, but not in Huh7 cells. The CNP1 and CNP2 potently inhibited HBV production by blocking viral proteins synthesis and reducing viral RNAs, respectively. In chronic hepatitis B patients, CNP was expressed in most of HBV-infected hepatocytes of liver specimens. Knockdown of CNP expression moderately improved viral production in the HepG2.2.15 cells treated with IFN-alpha. In conclusion, CNP might be a mediator of interferon-induced response against HBV.

语种英语
WOS记录号WOS:000327308500174
项目编号30972605 ; NCET-11-0011 ; D121100003912003 ; 2012ZX10002003
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Science and Technology Commission ; National Science and Technology Major Project for Infectious Diseases Control
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65058
专题北京大学第二临床医学院_北京大学肝病研究所
北京大学第二临床医学院_肝病科
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China
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GB/T 7714
Ma, Hui,Zhao, Xing-Liang,Wang, Xue-Yan,et al. 2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication[J]. PLOS ONE,2013,8(11).
APA Ma, Hui.,Zhao, Xing-Liang.,Wang, Xue-Yan.,Xie, Xing-Wang.,Han, Jin-Chao.,...&Wei, Lai.(2013).2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication.PLOS ONE,8(11).
MLA Ma, Hui,et al."2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication".PLOS ONE 8.11(2013).
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