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学科主题: 临床医学
题名:
2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication
作者: Ma, Hui; Zhao, Xing-Liang; Wang, Xue-Yan; Xie, Xing-Wang; Han, Jin-Chao; Guan, Wen-Li; Wang, Qin; Zhu, Lin; Pan, Xiao-Ben; Wei, Lai
刊名: PLOS ONE
发表日期: 2013-11-18
DOI: 10.1371/journal.pone.0080769
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: N-TERMINAL DOMAIN ; MEMBRANE ANCHOR ; GENE-EXPRESSION ; TRANSGENIC MICE ; C VIRUS ; INTERFERON ; PROTEIN ; SIGNAL ; CELLS ; IDENTIFICATION
英文摘要:

2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) is a member of the interferon-stimulated genes, which includes isoforms CNP1 and CNP2. CNP1 is locally expressed in the myelin sheath but CNP2 is additionally expressed at low levels outside the nervous system. CNPs regulate multiple cellular functions and suppress protein production by association with polyadenylation of mRNA. Polyadenylation of Hepatitis B virus (HBV) RNAs is crucial for HBV replication. Whether CNPs interact with polyadenylation signal of HBV RNAs and interfere HBV replication is unknown. In this study, we evaluated expressions of CNP isoforms in hepatoma cell lines and their effects on HBV replication. We found that CNP2 is moderately expressed and gently responded to interferon treatment in HepG2, but not in Huh7 cells. The CNP1 and CNP2 potently inhibited HBV production by blocking viral proteins synthesis and reducing viral RNAs, respectively. In chronic hepatitis B patients, CNP was expressed in most of HBV-infected hepatocytes of liver specimens. Knockdown of CNP expression moderately improved viral production in the HepG2.2.15 cells treated with IFN-alpha. In conclusion, CNP might be a mediator of interferon-induced response against HBV.

语种: 英语
所属项目编号: 30972605 ; NCET-11-0011 ; D121100003912003 ; 2012ZX10002003
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Science and Technology Commission ; National Science and Technology Major Project for Infectious Diseases Control
WOS记录号: WOS:000327308500174
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65058
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Hui,Zhao, Xing-Liang,Wang, Xue-Yan,et al. 2 ′,3 ′-Cyclic Nucleotide 3 ′-Phosphodiesterases Inhibit Hepatitis B Virus Replication[J]. PLOS ONE,2013,8(11).
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