北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 呼吸内科  > 期刊论文
学科主题: 临床医学
题名:
Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study
作者: Chang, Chun1; Zhu, Hong1; Shen, Ning1; Chen, Yahong1; He, Bei1; Zhao, Jiangchao2; Yao, Wanzhen1
关键词: CAT ; COPD ; exacerbation ; health status ; resolution ; symptom
刊名: COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
发表日期: 2015-02-01
DOI: 10.3109/15412555.2014.898043
卷: 12, 期:1, 页:19-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; ACUTE EXACERBATIONS ; COPD EXACERBATIONS ; INDUCED SPUTUM ; ANTIBIOTIC-THERAPY ; PREVENTION ; COLONIZATION ; VALIDATION ; MANAGEMENT ; FREQUENCY
英文摘要:

Bacterial infection is a major cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), which are associated with significantly increased airway and systemic inflammation. However, the relationship among bacteriology, the resolution of inflammation and clinical outcomes is largely unknown. In this study, we recruited consecutive patients hospitalized for AECOPD with purulent sputum. We measured the airway and systemic inflammation levels, the COPD assessment test (CAT) score and adverse outcomes between patients with and without potentially pathogenic microorganisms (PPM). Among sputum samples collected from the 135 episodes of AECOPD, 42 (31.1%) were PPM-positive at admission. Compared with those in the PPM-negative group, more patients in the PPM-positive group had >= 2 exacerbations in previous year and Anthonisen type I at admission and higher drop in sputum neutrophil, serum hs-CRP and CAT value from exacerbation to the subsequent baseline. No significant differences in the adverse outcomes between the two groups were observed. Among the 38 PPM-positive patients who survived and were discharged from hospital, 19 remained PPM-positive (bacterial persistence group) and 19 PPM-negative (bacterial clearance group). Both inflammation indices and CAT score decreased compared to admission in the two groups, regardless of the bacteriology at discharge. Our data suggest uncultivated bacteria and/or virus might also play important roles in causing inflammation and AECOPD.

语种: 英语
所属项目编号: 07010440052
项目资助者: Chinese Medical Association
WOS记录号: WOS:000349361700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65065
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
2.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA

Recommended Citation:
Chang, Chun,Zhu, Hong,Shen, Ning,et al. Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study[J]. COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,2015,12(1):19-30.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chang, Chun]'s Articles
[Zhu, Hong]'s Articles
[Shen, Ning]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chang, Chun]‘s Articles
[Zhu, Hong]‘s Articles
[Shen, Ning]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace