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学科主题临床医学
Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study
Chang, Chun1; Zhu, Hong1; Shen, Ning1; Chen, Yahong1; He, Bei1; Zhao, Jiangchao2; Yao, Wanzhen1
关键词CAT COPD exacerbation health status resolution symptom
刊名COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
2015-02-01
DOI10.3109/15412555.2014.898043
12期:1页:19-30
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; ACUTE EXACERBATIONS ; COPD EXACERBATIONS ; INDUCED SPUTUM ; ANTIBIOTIC-THERAPY ; PREVENTION ; COLONIZATION ; VALIDATION ; MANAGEMENT ; FREQUENCY
英文摘要

Bacterial infection is a major cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), which are associated with significantly increased airway and systemic inflammation. However, the relationship among bacteriology, the resolution of inflammation and clinical outcomes is largely unknown. In this study, we recruited consecutive patients hospitalized for AECOPD with purulent sputum. We measured the airway and systemic inflammation levels, the COPD assessment test (CAT) score and adverse outcomes between patients with and without potentially pathogenic microorganisms (PPM). Among sputum samples collected from the 135 episodes of AECOPD, 42 (31.1%) were PPM-positive at admission. Compared with those in the PPM-negative group, more patients in the PPM-positive group had >= 2 exacerbations in previous year and Anthonisen type I at admission and higher drop in sputum neutrophil, serum hs-CRP and CAT value from exacerbation to the subsequent baseline. No significant differences in the adverse outcomes between the two groups were observed. Among the 38 PPM-positive patients who survived and were discharged from hospital, 19 remained PPM-positive (bacterial persistence group) and 19 PPM-negative (bacterial clearance group). Both inflammation indices and CAT score decreased compared to admission in the two groups, regardless of the bacteriology at discharge. Our data suggest uncultivated bacteria and/or virus might also play important roles in causing inflammation and AECOPD.

语种英语
WOS记录号WOS:000349361700005
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65065
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100191, Peoples R China
2.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Chang, Chun,Zhu, Hong,Shen, Ning,et al. Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study[J]. COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,2015,12(1):19-30.
APA Chang, Chun.,Zhu, Hong.,Shen, Ning.,Chen, Yahong.,He, Bei.,...&Yao, Wanzhen.(2015).Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study.COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,12(1),19-30.
MLA Chang, Chun,et al."Bacterial Infection, Airway and Systemic Inflammation and Clinical Outcomes before and after Treatment of AECOPD, a Longitudinal and Cross-sectional Study".COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 12.1(2015):19-30.
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