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学科主题: 基础医学
题名:
Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy
作者: Torresi, J; Earnest-Silveira, L; Deliyannis, G; Edgtton, K; Zhuang, H; Locarnini, SA; Fyfe, J; Sozzi, T; Jackson, DC
关键词: hepatitis ; mutants ; vaccination ; lamivudine ; polymerase
刊名: VIROLOGY
发表日期: 2002-02-15
卷: 293, 期:2, 页:305-313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: INDUCED ESCAPE MUTANT ; SURFACE-ANTIGEN ; IMMUNE GLOBULIN ; VACCINE ; RESISTANCE ; VARIANTS ; YEAST ; MUTATIONS ; ANTIBODY ; EFFICACY
英文摘要:

The prevalence of hepatitis B virus vaccine escape mutants has increased as a consequence of the introduction of global vaccination programs. Furthermore and as a consequence of the organization of the genome of hepatitis B virus (HBV) into overlapping reading frames, the selection of polymerase mutants during long-term lamivudine therapy can select viruses with changes in the overlapping S gene coding for the hepatitis B small antigen (HBsAg). We have investigated the role of lamivudine in selecting HBV mutants with antigenically altered HBsAg protein using pooled human vaccinee sera in enzyme immunosorbent assays and radioimmunoassays. HBsAg proteins containing the vaccine escape mutations G145R and D144E/G145R demonstrated markedly reduced binding to anti-HBs antibody. HBsAg mutants including E164D, W196S, 1195M, M1981, and E164D/1196M (corresponding to the polymerase protein changes of V519L, M5501, L526M/MB50V V5531, and V519L/L526M/M550V) selected during lamivudine treatment also demonstrated reduced binding to anti-HBs antibody. These findings raise the possibility of lamivudine-resistant mutants arising that possess antigenically distinct HBsAg proteins. (C) 2002 Elsevier Science (USA).

语种: 英语
WOS记录号: WOS:000174378100012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65066
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3050, Australia
2.Univ Melbourne, Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia
3.Univ Melbourne, Victorian Infect Dis Reference Lab, Parkville, Vic 3050, Australia
4.Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3050, Australia
5.Beijing Med Univ, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Torresi, J,Earnest-Silveira, L,Deliyannis, G,et al. Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy[J]. VIROLOGY,2002,293(2):305-313.
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