IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro
Wang, Bin; Wang, Xue Mei; Fu, Hong; Liu, Geng Xin
关键词Alzheimer&prime s disease Wu-Zi-Yan-Zong-Fang amyloid beta
刊名YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
2009-08-01
129期:8页:941-948
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OXIDATIVE STRESS ; ALZHEIMERS-DISEASE ; ACETYLCHOLINESTERASE ACTIVITY ; MEMORY IMPAIRMENT ; RAT ; INVOLVEMENT ; PLASMA ; CELLS ; ASSAY ; DONEPEZIL
英文摘要

This study was designed to determine the effects of Wu-Zi-Yan-Zong-Fang on amyloid-beta(25-35)-induced cognitive deficits in rats and neurotoxicity in pheochromocytoma cells and the possible mechanism of action. In vivo studies showed that Wu-Zi-Yan-Zong-Fang significantly ameliorated the spatial memory and retention deficits, decreased acetylcholinesterase activity, and increased acetylcholine content caused by intracerebroventricular injection of amyloid-beta(25-35). In vitro results showed that Wu-Zi-Yan-Zong-Fang increased cell viability and the activity of superoxide dismutase and catalase and decreased the release of lactate dehydrogenase and the level of malondialdehyde. Wu-Zi-Yan-Zong-Fang also significantly reduced the percentage of apoptotic cells and blocked the increase in the intracellular concentration of Ca2+. These data suggest that Wu-Zi-Yan-Zong-Fang has potent protective effects for the treatment of Alzheimer′s disease in future.

语种英语
所属项目编号30672760
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000268554100005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65069
专题北京大学第一临床医学院
作者单位Peking Univ, Inst Integrat Tradit Chinese & Western Med, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Bin,Wang, Xue Mei,Fu, Hong,et al. Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,2009,129(8):941-948.
APA Wang, Bin,Wang, Xue Mei,Fu, Hong,&Liu, Geng Xin.(2009).Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro.YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,129(8),941-948.
MLA Wang, Bin,et al."Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro".YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129.8(2009):941-948.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Bin]的文章
[Wang, Xue Mei]的文章
[Fu, Hong]的文章
百度学术
百度学术中相似的文章
[Wang, Bin]的文章
[Wang, Xue Mei]的文章
[Fu, Hong]的文章
必应学术
必应学术中相似的文章
[Wang, Bin]的文章
[Wang, Xue Mei]的文章
[Fu, Hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。