| 学科主题 | 临床医学 |
| Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro | |
Wang, Bin; Wang, Xue Mei; Fu, Hong ; Liu, Geng Xin
| |
| 关键词 | Alzheimer&prime s disease Wu-Zi-Yan-Zong-Fang amyloid beta |
| 刊名 | YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
 |
| 2009-08-01 | |
| 卷 | 129期:8页:941-948 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | OXIDATIVE STRESS ; ALZHEIMERS-DISEASE ; ACETYLCHOLINESTERASE ACTIVITY ; MEMORY IMPAIRMENT ; RAT ; INVOLVEMENT ; PLASMA ; CELLS ; ASSAY ; DONEPEZIL |
| 英文摘要 | This study was designed to determine the effects of Wu-Zi-Yan-Zong-Fang on amyloid-beta(25-35)-induced cognitive deficits in rats and neurotoxicity in pheochromocytoma cells and the possible mechanism of action. In vivo studies showed that Wu-Zi-Yan-Zong-Fang significantly ameliorated the spatial memory and retention deficits, decreased acetylcholinesterase activity, and increased acetylcholine content caused by intracerebroventricular injection of amyloid-beta(25-35). In vitro results showed that Wu-Zi-Yan-Zong-Fang increased cell viability and the activity of superoxide dismutase and catalase and decreased the release of lactate dehydrogenase and the level of malondialdehyde. Wu-Zi-Yan-Zong-Fang also significantly reduced the percentage of apoptotic cells and blocked the increase in the intracellular concentration of Ca2+. These data suggest that Wu-Zi-Yan-Zong-Fang has potent protective effects for the treatment of Alzheimer′s disease in future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000268554100005 |
| 项目编号 | 30672760 |
| 资助机构 | National Natural Science Foundation of China |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/65069 |
| 专题 | 北京大学第一临床医学院 北京大学第一临床医学院_中医中西医结合科 |
| 作者单位 | Peking Univ, Inst Integrat Tradit Chinese & Western Med, Hosp 1, Beijing 100034, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Bin,Wang, Xue Mei,Fu, Hong,et al. Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,2009,129(8):941-948. |
| APA | Wang, Bin,Wang, Xue Mei,Fu, Hong,&Liu, Geng Xin.(2009).Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro.YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,129(8),941-948. |
| MLA | Wang, Bin,et al."Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid beta-induced Damage In Vivo and In Vitro".YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129.8(2009):941-948. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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