|FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese|
|Zhou, Xu-jie; Lv, Ji-cheng; Yu, Lei; Cui, Zhao; Zhao, Juan; Yang, Rui; Han, Jia; Hou, Ping; Zhao, Ming-hui; Zhang, Hong1|
|关键词||anti-glomerular basement membrane antibody disease Fc gamma receptors FCGR gene polymorphism|
|刊名||NEPHROLOGY DIALYSIS TRANSPLANTATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Transplantation ; Urology & Nephrology|
|研究领域[WOS]||Transplantation ; Urology & Nephrology|
|关键词[WOS]||SYSTEMIC-LUPUS-ERYTHEMATOSUS ; BASEMENT-MEMBRANE DISEASE ; FC-GAMMA RECEPTORS ; NEPHROTOXIC NEPHRITIS ; GOODPASTURES-DISEASE ; AUTOIMMUNE-DISEASE ; JAPANESE PATIENTS ; LIPID RAFTS ; SUSCEPTIBILITY ; CELLS|
Methods. A total of 48 patients with anti-GBM disease and 225 geographically and ethnically matched healthy controls were involved. Genotyping of the previously identified polymorphisms FCGR2A131H/R (rs1801274), FCGR2B 232I/T (rs1050501) and FCGR3A176F/V (rs396991) were detected by the TaqMan genotyping assay and FCGR3B NA1/2 by the PCR-sequence specific primer (SSP). Allele type, genotype and haplotype of identified polymorphisms were analysed between patients and controls.
Results. Our results revealed that FCGR2A131H/R, FCGR3A176F/V and FCGR3B NA1/2 were not associated with anti-GBM disease. The frequency of the FCGR2B 232T allele (30.2% versus 15.6%, corrected P = 0.00028, 95% CI: 1.42-3.89) and genotypes of I232T (60.4% versus 31.1%, corrected P = 0.0004, 95% CI: 1.78-6.43) was significantly increased in patients compared with controls.
Conclusion. The present study demonstrates the genetic association of polymorphism of FCGR2B (I232T) with susceptibility to anti-GBM disease in Chinese.
|项目编号||30801022 ; 30825021 ; 200802052|
|资助机构||National Natural Science Foundation of China ; Foundation of Ministry of Health of China|
|作者单位||1.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal, Beijing 100034, Peoples R China|
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
|Zhou, Xu-jie,Lv, Ji-cheng,Yu, Lei,et al. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2010,25(1):97-101.|
|APA||Zhou, Xu-jie.,Lv, Ji-cheng.,Yu, Lei.,Cui, Zhao.,Zhao, Juan.,...&Zhang, Hong.(2010).FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese.NEPHROLOGY DIALYSIS TRANSPLANTATION,25(1),97-101.|
|MLA||Zhou, Xu-jie,et al."FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese".NEPHROLOGY DIALYSIS TRANSPLANTATION 25.1(2010):97-101.|