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FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese
Zhou, Xu-jie; Lv, Ji-cheng; Yu, Lei; Cui, Zhao; Zhao, Juan; Yang, Rui; Han, Jia; Hou, Ping; Zhao, Ming-hui; Zhang, Hong1
关键词anti-glomerular basement membrane antibody disease Fc gamma receptors FCGR gene polymorphism
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2010
DOI10.1093/ndt/gfp374
25期:1页:97-101
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; BASEMENT-MEMBRANE DISEASE ; FC-GAMMA RECEPTORS ; NEPHROTOXIC NEPHRITIS ; GOODPASTURES-DISEASE ; AUTOIMMUNE-DISEASE ; JAPANESE PATIENTS ; LIPID RAFTS ; SUSCEPTIBILITY ; CELLS
英文摘要

Methods. A total of 48 patients with anti-GBM disease and 225 geographically and ethnically matched healthy controls were involved. Genotyping of the previously identified polymorphisms FCGR2A131H/R (rs1801274), FCGR2B 232I/T (rs1050501) and FCGR3A176F/V (rs396991) were detected by the TaqMan genotyping assay and FCGR3B NA1/2 by the PCR-sequence specific primer (SSP). Allele type, genotype and haplotype of identified polymorphisms were analysed between patients and controls.

Results. Our results revealed that FCGR2A131H/R, FCGR3A176F/V and FCGR3B NA1/2 were not associated with anti-GBM disease. The frequency of the FCGR2B 232T allele (30.2% versus 15.6%, corrected P = 0.00028, 95% CI: 1.42-3.89) and genotypes of I232T (60.4% versus 31.1%, corrected P = 0.0004, 95% CI: 1.78-6.43) was significantly increased in patients compared with controls.

Conclusion. The present study demonstrates the genetic association of polymorphism of FCGR2B (I232T) with susceptibility to anti-GBM disease in Chinese.

语种英语
WOS记录号WOS:000273113100018
项目编号30801022 ; 30825021 ; 200802052
资助机构National Natural Science Foundation of China ; Foundation of Ministry of Health of China
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65076
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
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GB/T 7714
Zhou, Xu-jie,Lv, Ji-cheng,Yu, Lei,et al. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2010,25(1):97-101.
APA Zhou, Xu-jie.,Lv, Ji-cheng.,Yu, Lei.,Cui, Zhao.,Zhao, Juan.,...&Zhang, Hong.(2010).FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese.NEPHROLOGY DIALYSIS TRANSPLANTATION,25(1),97-101.
MLA Zhou, Xu-jie,et al."FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese".NEPHROLOGY DIALYSIS TRANSPLANTATION 25.1(2010):97-101.
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