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Essential role of protein kinase C in morphine-induced rewarding memory
Ping, Xingjie1,2,3,4; Ma, Yaoying1,2,3,4; Li, Yijing1,2,3,4; Qi, Chong1,2,3,4; Sun, Xiaowei1,2,3,4; Lv, Xiufang1,2,3,4; Cui, Cailian1,2,3,4
关键词Nucleus accumbens Morphine-conditioned place preference Protein kinase C Protein kinase C gamma gamma V5-3
刊名NEUROPHARMACOLOGY
2012-02-01
DOI10.1016/j.neuropharm.2011.10.001
62期:2页:959-966
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
资助者National Natural Science Foundation ; National Basic Research Program of China ; National Natural Science Foundation ; National Basic Research Program of China
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]NMDA RECEPTOR ; NUCLEUS-ACCUMBENS ; MESSENGER-RNA ; GAMMA ISOFORM ; RAT FOREBRAIN ; PHORBOL ESTER ; INDUCED CPP ; DEPENDENCE ; PKC ; EXPRESSION
英文摘要

Protein kinase C (PKC) is involved in intra-cellular signal transduction in various physiological and pathological processes including substance abuse. In the present study, the role of PKC in morphine-induced rewarding memory was investigated using the conditioned place preference (CPP) model. We found a significant translocation of PKCs from cytosol to membrane component in nucleus accumbens (NAc) of morphine-conditioned rats in a dose-dependent manner. The translocation was reduced gradually with the maintenance of morphine-induced CPP. Specifically, the protein level of PKC gamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKC gamma in cytosol of the NAc showed an opposite change. Furthermore, the PKC translocation inhibitor gamma V5-3 impaired the morphine-induced CPP when microinjected into the NAc. These findings indicated that PKC, especially the gamma isoform, is essential for the acquisition and maintenance of morphine-associated reward memory.

This article is part of a Special Issue entitled ′Post-Traumatic Stress Disorder′. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30970933 ; 2009CB522003
资助者National Natural Science Foundation ; National Basic Research Program of China ; National Natural Science Foundation ; National Basic Research Program of China
WOS记录号WOS:000301549300045
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65080
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
4.Minist Publ Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Ping, Xingjie,Ma, Yaoying,Li, Yijing,et al. Essential role of protein kinase C in morphine-induced rewarding memory[J]. NEUROPHARMACOLOGY,2012,62(2):959-966.
APA Ping, Xingjie.,Ma, Yaoying.,Li, Yijing.,Qi, Chong.,Sun, Xiaowei.,...&Cui, Cailian.(2012).Essential role of protein kinase C in morphine-induced rewarding memory.NEUROPHARMACOLOGY,62(2),959-966.
MLA Ping, Xingjie,et al."Essential role of protein kinase C in morphine-induced rewarding memory".NEUROPHARMACOLOGY 62.2(2012):959-966.
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