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学科主题: 临床医学
题名:
Activation of the canonical nuclear factor-kappa B pathway is involved in isoflurane-induced hippocampal interleukin-1 beta elevation and the resultant cognitive deficits in aged rats
作者: Li, Zheng-Qian1; Rong, Xiao-Ying1; Liu, Ya-Jie1; Ni, Cheng1; Tian, Xiao-Sheng2,3,4; Mo, Na5; Chui, De-Hua2,3,4; Guo, Xiang-Yang1
关键词: Postoperative cognitive dysfunction ; Isoflurane ; NF-kappa B ; Interleukin-1 beta
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2013-09-06
DOI: 10.1016/j.bbrc.2013.08.003
卷: 438, 期:4, 页:628-634
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: PYRROLIDINE DITHIOCARBAMATE ; DYSFUNCTION ; INJURY ; CELLS ; EXPRESSION
英文摘要:

Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear factor (NF)-kappa B signaling, and to explore its association with hippocampal interleukin (IL)-1 beta levels and anesthetic-related cognitive changes in aged rats. After a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increases in I kappa B kinase and I kappa B phosphorylation, as well as a reduction in the NF-kappa B inhibitory protein (I kappa B alpha), were observed in the hippocampi of isoflurane-exposed rats compared with control rats. These events were accompanied by an increase in NF-kappa B p65 nuclear translocation at 6 h after isoflurane exposure and hippocampal IL-1 beta elevation from 1 to 6 h after isoflurane exposure. Nevertheless, no significant neuroglia activation was observed. Pharmacological inhibition of NF-kappa B activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1 beta increase and NF-kappa B signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal partially via activation of the canonical NF-kappa B pathway, in aged rats. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81241040 ; 81171015 ; 20110001110008 ; 2012CB911004
项目资助者: National Natural Science Foundation of China ; Doctoral Fund of the Ministry of Education of China ; NHTR of China
WOS记录号: WOS:000324454800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65081
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Neurobiol,Key Lab Neurosci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100191, Peoples R China
5.Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100021, Peoples R China

Recommended Citation:
Li, Zheng-Qian,Rong, Xiao-Ying,Liu, Ya-Jie,et al. Activation of the canonical nuclear factor-kappa B pathway is involved in isoflurane-induced hippocampal interleukin-1 beta elevation and the resultant cognitive deficits in aged rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,438(4):628-634.
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