IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心
学科主题临床医学
Detection of Epstein-Barr virus infection in cancer by using highly specific nanoprobe based on dBSA capped CdTe quantum dots
Li, Yilin1,2; Jing, Lihong2; Ding, Ke2; Gao, Jing1; Peng, Zhi1; Li, Yanyan1; Shen, Lin1; Gao, Mingyuan2
刊名RSC ADVANCES
2014
DOI10.1039/c4ra02277g
4期:43页:22545-22550
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者NSFC projects ; National Basic Research Program of China ; National High Technology Research and Development Program of China ; Beijing Municipal Science and Technology Commission Program ; NSFC projects ; National Basic Research Program of China ; National High Technology Research and Development Program of China ; Beijing Municipal Science and Technology Commission Program
研究领域[WOS]Chemistry
关键词[WOS]REVERSE MICROEMULSION METHOD ; IN-VIVO ; SEMICONDUCTOR NANOCRYSTALS ; AQUEOUS SYNTHESIS ; SERUM ; MICROSPHERES ; PARTICLES ; CDSE ; PHOTOLUMINESCENCE ; ADSORPTION
英文摘要

By using denatured bovine serum albumin (dBSA) molecules as multidentate ligands, surface-functionalized CdTe quantum dots (QDs) were synthesized and further evaluated for preparing fluorescent probes capable of detecting Epstein-Barr virus infection. The optical studies revealed that the dBSA coating effectively improved the optical stability of the resulting QDs (CdTe@dBSA). The interaction between CdTe@dBSA and the membrane of carcinoma cells further suggested that the nonspecific adsorption of CdTe QDs stabilized by thioglycolic acid (TGA) was significantly eliminated upon the dBSA coating. Streptavidin was covalently conjugated to CdTe@dBSA to endow the QDs with specific binding affinity in detecting the serum level of anti-Epstein-Barr virus (EBV) capsid antigen IgA (VCA-IgA) in nasopharyngeal carcinoma patients for early screening and diagnosing EBV-associated cancers.

语种英语
所属项目编号81301323 ; 81172110 ; 21203210 ; 2011CB935800 ; 2012AA 02A 504 ; Z11110706730000
资助者NSFC projects ; National Basic Research Program of China ; National High Technology Research and Development Program of China ; Beijing Municipal Science and Technology Commission Program ; NSFC projects ; National Basic Research Program of China ; National High Technology Research and Development Program of China ; Beijing Municipal Science and Technology Commission Program
WOS记录号WOS:000337124900035
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65085
Collection北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Peking Univ, Canc Hosp & Inst, Dept GI Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Yilin,Jing, Lihong,Ding, Ke,et al. Detection of Epstein-Barr virus infection in cancer by using highly specific nanoprobe based on dBSA capped CdTe quantum dots[J]. RSC ADVANCES,2014,4(43):22545-22550.
APA Li, Yilin.,Jing, Lihong.,Ding, Ke.,Gao, Jing.,Peng, Zhi.,...&Gao, Mingyuan.(2014).Detection of Epstein-Barr virus infection in cancer by using highly specific nanoprobe based on dBSA capped CdTe quantum dots.RSC ADVANCES,4(43),22545-22550.
MLA Li, Yilin,et al."Detection of Epstein-Barr virus infection in cancer by using highly specific nanoprobe based on dBSA capped CdTe quantum dots".RSC ADVANCES 4.43(2014):22545-22550.
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