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学科主题: 临床医学
题名:
Transferrin-modified PLGA nanoparticles significantly increase the cytotoxicity of paclitaxel in bladder cancer cells by increasing intracellular retention
作者: Jin, Shihua; Zhang, Yi; Yu, Chengfan; Wang, Gang; Zhang, Zhihong; Li, Ningchen; Na, Yanqun
关键词: Poly(D,L lactide-co-glycolide) ; Polyvinyl alcohol ; Nanoparticle ; Paclitaxel ; Urothelium tumor ; Transferrin ; Nanomedicine
刊名: JOURNAL OF NANOPARTICLE RESEARCH
发表日期: 2014-09-12
DOI: 10.1007/s11051-014-2639-0
卷: 16, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: POLY D,L-LACTIDE-CO-GLYCOLIDE NANOPARTICLES ; TISSUE UPTAKE ; IN-VITRO ; DELIVERY ; DRUG ; DOXORUBICIN
英文摘要:

To improve the anticancer effects of paclitaxel (Tax) on bladder cancer, transferrin-modified and unmodified poly(D,L lactide-co-glycolide) nanoparticles (NPs) were generated to deliver Tax. The characteristics of the NPs and the drug-release profiles were evaluated. The cytotoxicity levels of blank NPs and Tax-loaded NPs in the bladder cancer cell lines MBT-2, J-82, and TCC Sup were determined. The uptakes and retentions of the NPs by the cell lines and the intracellular distribution of the NPs were also studied. The results showed similar NPs characteristics and drug-release profiles for NPs with and without transferrin modification. The sizes of NPs with and without transferrin modification were 206 and 278 nm, respectively; the Z-potentials were-23.5 and - 24.3 mV, respectively; the drug loadings were 6.5 and 6.7% w/w, respectively. No cytotoxicity was observed in the bladder cancer cells exposed to blank NPs. Both types of Tax-loaded NPs, however, had significantly higher cytotoxicity levels compared with the Tax solution in the bladder cancer cells. The transferrin-modified, Tax-loaded NPs were significantly more cytotoxic than the Tax-loaded NPs without modification in the MBT-2 and TCC Sup cells. There were no significant differences in NP uptakes between transferrin-modified and unmodified NPs in any of the three studied bladder cancer cell lines; however, the retentions of the modified NPs were significantly higher in the MBT-2 and TCC Sup cells. These findings suggest that NPs can significantly improve the anticancer effect of Tax in bladder cells. Furthermore, transferrin-modified NPs can improve the anticancer effect by increasing intracellular retention and not by increasing uptake. The transferrin-modified NPs are promising drug delivery vehicle for bladder cancer treatment.

语种: 英语
WOS记录号: WOS:000349948400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65087
Appears in Collections:北京大学首钢医院_期刊论文

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作者单位: Peking Univ, Shougang Hosp, Wujieping Urol Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Jin, Shihua,Zhang, Yi,Yu, Chengfan,et al. Transferrin-modified PLGA nanoparticles significantly increase the cytotoxicity of paclitaxel in bladder cancer cells by increasing intracellular retention[J]. JOURNAL OF NANOPARTICLE RESEARCH,2014,16(10).
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