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学科主题: 临床医学
题名:
Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial
作者: Li, Haibo1; Qin, Xianhui1; Xie, Di2; Tang, Genfu1; Zhang, Yan3; Li, Jianping3; Hou, Fanfan2; Wang, Xiaobin4; Huo, Yong3; Xu, Xiping1
关键词: folic acid ; uric acid ; hypertension ; randomized ; controlled trial
刊名: INTERNAL MEDICINE
发表日期: 2015
DOI: 10.2169/internalmedicine.54.2931
卷: 54, 期:1, 页:17-24
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: METHYLENETETRAHYDROFOLATE REDUCTASE GENE ; CARDIOVASCULAR-DISEASE ; BLOOD-PRESSURE ; RISK-FACTORS ; INCIDENT HYPERTENSION ; XANTHINE-OXIDASE ; HYPERURICEMIA ; HOMOCYSTEINE ; PLASMA ; METAANALYSIS
英文摘要:

Objective The efficacy of combined treatment consisting of enalapril and folic acid (FA) was compared to that of enalapril alone in reducing the serum uric acid (UA) levels in adult hypertensive patients in China.

Methods Patients with mild to moderate hypertension (n=480) were randomly assigned to one of three treatment groups: (1) 10 mg enalapril (control group), (2) 10 mg enalapril plus 0.4 mg FA (low-FA group) or (3) 10 mg enalapril plus 0.8 mg FA (high-FA group) daily for eight weeks. The primary outcome was the UA ratio (week 8 UA: baseline UA).

Results The final analysis included 450 patients (43.1% men, 27-75 years of age). An adjusted multivariable regression analysis revealed no significant differences in the UA ratio between the three groups after eight weeks of treatment. In the subgroup analysis stratified according to the baseline UA level, the high-FA group demonstrated a significantly greater UA-lowering response among the patients with an elevated baseline UA concentration (UA >= 310 mu mol/L) [median UA ratio (25th percentile, 75th percentile): 0.94 (0.83, 1.01)], compared with that observed in the control group [0.97 (0.90, 1.00), p=0.025]. Similar results were found in the participants with baseline hyperuricemia (HUA; UA: men >420 mu mol/L, women >350 mu mol/L).

Conclusion In this sample of adult hypertensive patients, the administration of a daily dose of 10 mg of enalapril combined with 0.8 mg of FA had a greater beneficial effect on the serum UA levels than did that of 10 mg of enalapril alone in patients with either an elevated UA concentration or HUA.

语种: 英语
所属项目编号: 2012CB517703 ; 2012zx09101105
项目资助者: Major State Basic Research Development Program of China (973 program) ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000347451600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65089
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing, Peoples R China
3.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
4.Johns Hopkins Univ, Ctr Early Life Origins Dis, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD 21218 USA

Recommended Citation:
Li, Haibo,Qin, Xianhui,Xie, Di,et al. Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial[J]. INTERNAL MEDICINE,2015,54(1):17-24.
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