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Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial
Li, Haibo1; Qin, Xianhui1; Xie, Di2; Tang, Genfu1; Zhang, Yan3; Li, Jianping3; Hou, Fanfan2; Wang, Xiaobin4; Huo, Yong3; Xu, Xiping1
关键词folic acid uric acid hypertension randomized controlled trial
刊名INTERNAL MEDICINE
2015
DOI10.2169/internalmedicine.54.2931
54期:1页:17-24
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]METHYLENETETRAHYDROFOLATE REDUCTASE GENE ; CARDIOVASCULAR-DISEASE ; BLOOD-PRESSURE ; RISK-FACTORS ; INCIDENT HYPERTENSION ; XANTHINE-OXIDASE ; HYPERURICEMIA ; HOMOCYSTEINE ; PLASMA ; METAANALYSIS
英文摘要

Objective The efficacy of combined treatment consisting of enalapril and folic acid (FA) was compared to that of enalapril alone in reducing the serum uric acid (UA) levels in adult hypertensive patients in China.

Methods Patients with mild to moderate hypertension (n=480) were randomly assigned to one of three treatment groups: (1) 10 mg enalapril (control group), (2) 10 mg enalapril plus 0.4 mg FA (low-FA group) or (3) 10 mg enalapril plus 0.8 mg FA (high-FA group) daily for eight weeks. The primary outcome was the UA ratio (week 8 UA: baseline UA).

Results The final analysis included 450 patients (43.1% men, 27-75 years of age). An adjusted multivariable regression analysis revealed no significant differences in the UA ratio between the three groups after eight weeks of treatment. In the subgroup analysis stratified according to the baseline UA level, the high-FA group demonstrated a significantly greater UA-lowering response among the patients with an elevated baseline UA concentration (UA >= 310 mu mol/L) [median UA ratio (25th percentile, 75th percentile): 0.94 (0.83, 1.01)], compared with that observed in the control group [0.97 (0.90, 1.00), p=0.025]. Similar results were found in the participants with baseline hyperuricemia (HUA; UA: men >420 mu mol/L, women >350 mu mol/L).

Conclusion In this sample of adult hypertensive patients, the administration of a daily dose of 10 mg of enalapril combined with 0.8 mg of FA had a greater beneficial effect on the serum UA levels than did that of 10 mg of enalapril alone in patients with either an elevated UA concentration or HUA.

语种英语
WOS记录号WOS:000347451600004
项目编号2012CB517703 ; 2012zx09101105
资助机构Major State Basic Research Development Program of China (973 program) ; Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65089
专题北京大学第一临床医学院_心血管内科
作者单位1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing, Peoples R China
3.Southern Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
4.Johns Hopkins Univ, Ctr Early Life Origins Dis, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD 21218 USA
推荐引用方式
GB/T 7714
Li, Haibo,Qin, Xianhui,Xie, Di,et al. Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial[J]. INTERNAL MEDICINE,2015,54(1):17-24.
APA Li, Haibo.,Qin, Xianhui.,Xie, Di.,Tang, Genfu.,Zhang, Yan.,...&Xu, Xiping.(2015).Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial.INTERNAL MEDICINE,54(1),17-24.
MLA Li, Haibo,et al."Effects of Combined Enalapril and Folic Acid Therapy on the Serum Uric Acid Levels in Hypertensive Patients: A Multicenter, Randomized, Double-blind, Parallel-controlled Clinical Trial".INTERNAL MEDICINE 54.1(2015):17-24.
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