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Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection
Che, W.2; Liu, W.1; Wei, Y.2; Xu, Y.2; Hou, L.2; Matsumori, A.3; Hu, D.1
关键词diastolic dysfunction echocardiography HCV infection NT-proBNP
刊名JOURNAL OF VIRAL HEPATITIS
2012-05-01
DOI10.1111/j.1365-2893.2011.01551.x
19期:5页:327-331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]HEART-FAILURE ; BNP ; MYOCARDITIS ; IMPACT ; RISK
英文摘要

Prior studies demonstrated that patients with hepatitis C virus (HCV) infection had higher plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, which may indicate the presence of a subclinical cardiac dysfunction. However, there are few data regarding the echocardiographic assessment in HCV-infected patients. The objectives of this study were to investigate changes in the left ventricle (LV) with echocardiography and to identify echocardiographic correlates of serum NT-proBNP levels in HCV-infected patients. Ninety HCV-infected patients and 90 age and gender-matched healthy controls were included. The level of serum NT-proBNP was higher in the patient group (P < 0.001). The proportion of patients whose serum NT-proBNP levels were higher than 125 pg/mL was greater than that of controls (15.56%vs 3.33%, P = 0.011). Echocardiography did not show any significant difference of cardiac structural abnormalities between groups. In the patient group, E, E′ and E/A were lower, and E/E′ was higher. The proportion of patients (13, 14.44%) with impaired diastolic filling (E/A = 0.75; 0.75 < E/A < 1.5 and E/E′ = 10) was greater than that of the control group (3, 3.33%; P = 0.018). Simple regression analysis demonstrated a statistically significant linear correlation between NT-proBNP levels and left ventricular diastolic diameter (LVDd) (r = 0.178, P = 0.013), left ventricular posterior wall diastolic thickness (LVPWd) (r = 0.147, P = 0.023) and mitral E/E (r = 0.414, P = 0.027). Independent correlates of NT-proBNP levels (R2 = 0.34) were older age (beta′ = 0.034, P = 0.011) and E/E ratio (beta′ = 0.026, P = 0.018). In conclusion, the combined analysis of NT-proBNP and echocardiography showed a possible subclinical left ventricular diastolic dysfunction as evidence of a pathogenic link between HCV and CVD.

语种英语
WOS记录号WOS:000302800600004
项目编号11ZR1428200 ; 2009KJ011
资助机构Shanghai Natural Science Foundation of China ; Natural Science Foundation of Tongji University
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65091
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China
2.Tongji Univ, Sch Med, Dept Cardiol, Shanghai Peoples Hosp 10, Shanghai 200092, Peoples R China
3.Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Kyoto, Japan
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GB/T 7714
Che, W.,Liu, W.,Wei, Y.,et al. Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection[J]. JOURNAL OF VIRAL HEPATITIS,2012,19(5):327-331.
APA Che, W..,Liu, W..,Wei, Y..,Xu, Y..,Hou, L..,...&Hu, D..(2012).Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection.JOURNAL OF VIRAL HEPATITIS,19(5),327-331.
MLA Che, W.,et al."Increased serum N-terminal pro-B-type natriuretic peptide and left ventricle diastolic dysfunction in patients with hepatitis C virus infection".JOURNAL OF VIRAL HEPATITIS 19.5(2012):327-331.
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